Publications by authors named "A Zarzour"
Undifferentiated pleomorphic sarcoma (UPS) is the largest subgroup of soft tissue sarcomas. This study determined the value of perfusion-weighted imaging with dynamic-contrast-enhancement (PWI/DCE) morphologic, qualitative, and semiquantitative features for predicting UPS pathology-assessed treatment effect (PATE). This retrospective study included 33 surgically excised extremity UPS patients with pre-surgical MRI.
View Article and Find Full Text PDFIntroduction: Data on prior use of Tenecteplase versus Alteplase in acute stroke management by mechanical thrombectomy are controversial. Our primary objective was to make a comprehensive comparative assessment of clinical and angiographic efficacy and safety outcomes in a large prospective observational study.
Methods: We included stroke patients who were eligible for intravenous thrombolysis and endovascular thrombectomy between 2019 and 2021, from an ongoing registry in twenty comprehensive stroke centers in France.
Objective: Impaired adipogenic differentiation exacerbates metabolic disease in obesity. This study reported that high-fat diet (HFD)-fed mice housed at thermoneutrality exhibited impaired adipogenic differentiation, attributed to increased expression of histone deacetylase 9 (HDAC9). However, the impact of HFD on adipogenic differentiation is reportedly variable, possibly reflecting divergent environmental conditions such as housing temperature.
View Article and Find Full Text PDFBackground: Concerns regarding potential neurologic complications of COVID-19 are being increasingly reported worldwide. Our objective was to investigate the neurologic complications of COVID-19 among a cohort of Lebanese patients with SARS-CoV-2 infection admitted to Rafik Hariri University Hospital (RHUH), the leading COVID-19 testing and treatment center in Lebanon.
Methods: This is a retrospective, single-center, observational study conducted from March to July 2020 at RHUH, Lebanon.
Article Synopsis
- Undifferentiated pleomorphic sarcoma (UPS) shows significant immune infiltration, with immune checkpoint inhibitors benefiting around 20% of patients, leading to an investigation of the tumor's immune microenvironment and its impact on patient outcomes.
- Researchers performed immunohistochemistry on 105 surgically removed UPS samples, assessing various immune markers and correlations related to overall and disease-free survival using statistical methods.
- Key findings revealed that certain immune markers (like CD39 and CD73) were linked to treatment responsiveness and survival rates, with significant variations seen in primary vs. recurrent and metastatic tumors, highlighting the complexity of immune interactions in UPS.