Growth hormone (GH) response to clonidine and growth hormone-releasing hormone (GHRH) stimulation, together with baseline somatomedin C (SmC) levels, were examined in parallel in a group of 21 patients with anorexia nervosa (AN) and in 10 controls. In addition, the Hamilton Rating Scale for Depression (HRS) was administered to the patients. Clonidine (2.
View Article and Find Full Text PDFLiterature data show that TRH may have either stimulatory or inhibitory actions on GH release according to pathophysiological conditions of the subject. In view of this dual effect of TRH, we studied the possible interaction of TRH and GRF on GH secretion. Six healthy male volunteers received iv in different occasions and in random order: 1) GRF 0.
View Article and Find Full Text PDFBoth naloxone, a specific opiate antagonist, and caffeine and other components of coffee powders show influences on opiate receptors and on the secretion of some pituitary hormones. In order to study the possible effect of naloxone and coffee on the secretion pattern of hypophyseal hormones in man, experiments were performed in normal volunteers using either naloxone or coffee alone or both substances. Five healthy normal males, aged 25-30 years, received on three separate occasions and in random order: (i) coffee (4 cups of Italian style "espresso" coffee); or (ii) naloxone 12 micrograms/kg i.
View Article and Find Full Text PDFInt J Clin Pharmacol Res
July 1985
Flunoxaprofen S-(+)-2 [p-fluorophenyl]-alpha-methyl-5-benzoxazole acetic acid, a new propionic acid derivative, was studied to investigate its long-term effectiveness and tolerability in the management of osteoarthritis (OA). To the study were admitted 154 patients suffering from radiologically proven OA of the large joints; 37% of them were hospitalized. The patients received flunoxaprofen 100 mg twice daily for a period of 45-60 days.
View Article and Find Full Text PDFClin Endocrinol (Oxf)
November 1984
Some evidence suggests the existence of a histaminergic influence on GH secretion in animals and man. We used cimetidine, a specific H2-receptor antagonist, to study the possible interference of H2-receptor blockade on plasma GH release by L-dopa and on PRL inhibition by L-dopa in normal man. Seven healthy normal male volunteers aged 23-36 years received a single oral dose of L-dopa (500 mg) or an i.
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