Publications by authors named "A Zanca"
Coordination of cell behaviour is key to a myriad of biological processes including tissue morphogenesis, wound healing, and tumour growth. As such, individual-based computational models, which explicitly describe inter-cellular interactions, are commonly used to model collective cell dynamics. However, when using individual-based models, it is unclear how descriptions of cell boundaries affect overall population dynamics.
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- The study investigated the increasing prevalence of endometrial cancer and aimed to improve molecular classification and detection using non-invasive cervicovaginal samples.
- It included 139 patients with endometrial cancer and 107 controls, analyzing a total of 339 samples through next-generation sequencing (NGS) to identify genetic mutations.
- Results showed that 73% of cancer cases had detectable mutations, with varying prognoses based on specific mutations, highlighting the potential of using non-invasive methods for better diagnosis and treatment.
Genetically encoded optical sensors and advancements in microscopy instrumentation and techniques have revolutionized the scientific toolbox available for probing complex biological processes such as release of specific neurotransmitters. Most genetically encoded optical sensors currently used are based on fluorescence and have been highly successful tools for single-cell imaging in superficial brain regions. However, there remains a need to develop new tools for reporting neuronal activity within deeper structures without the need for hardware such as lenses or fibers to be implanted within the brain.
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- Screenwide is a case-control study conducted in Spain from 2017 to 2021 that looked at women with endometrial and ovarian cancers, along with BRCA1/2 and MMR pathogenic variant carriers, to identify risk factors and molecular biomarkers for these cancers.
- Participants provided detailed personal and medical information, along with biological samples like blood and self-collected vaginal specimens, to facilitate comprehensive analyses.
- Preliminary findings from a pilot study indicate that certain genetic variants associated with tumors can be effectively detected in less invasive samples, suggesting potential for improved early detection strategies for gynecological cancers.
Chronic wounds, such as venous leg ulcers, are difficult to treat and can reduce the quality of life for patients. Clinical trials have been conducted to identify the most effective venous leg ulcer treatments and the clinical factors that may indicate whether a wound will successfully heal. More recently, mathematical modelling has been used to gain insight into biological factors that may affect treatment success but are difficult to measure clinically, such as the rate of oxygen flow into wounded tissue.
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