Publications by authors named "A Zambelli"
Article Synopsis
- CDK4/6 inhibitors have greatly improved treatment for hormone receptor-positive breast cancer, but developing resistance to these drugs remains a significant issue with few guidelines for alternative treatments.
- Continuing CDK4/6 inhibition, possibly alongside endocrine therapy or new drugs, is an active area of research that may change treatment practices based on the results of ongoing clinical trials.
- Evidence suggests switching to a different CDK4/6 inhibitor after progression can have limited benefits, and current biomarker analyses for patient selection have been inconsistent, indicating that further research and validation are necessary before making this approach standard practice.
Article Synopsis
- Breast cancer (BC) is the most common cancer affecting women worldwide, with millions diagnosed each year.
- Research and treatment options continue to evolve, aiming to improve outcomes for patients.
- Awareness campaigns and early detection efforts play a crucial role in reducing mortality rates associated with BC.
Introduction: The growing evidence of increased life expectancy in the future reveals the high relevance of frailty in patients with chronic-degenerative diseases; identification and management of symptoms may improve significantly their quality of life. The objective of our study was to assess the symptom burden in patients with advanced chronic or prolonged infectious diseases.
Materials And Methods: A cross-sectional study was performed enrolling 88 patients, referred to palliative care consultation for chronic pain, and evaluated using the Edmonton Symptom Assessment System to define Total Symptom Distress Score (TSDS) and high symptom burden (HSB) when more than six symptoms along with Numerical Rating Scale ≥4 were present.