Publications by authors named "A Zaleski"
Possible Impact of Peripheral Inflammatory Factors and Interleukin-1β (IL-1β) on Cognitive Functioning in Progressive Supranuclear Palsy-Richardson Syndrome (PSP-RS) and Progressive Supranuclear Palsy-Predominant Parkinsonism (PSP-P).
Int J Mol Sci
December 2024
Progressive supranuclear palsy (PSP) is a tauopathic atypical parkinsonian syndrome. Recent studies suggest that inflammation may play a role in PSP pathogenesis, highlighting markers like the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and cytokines such as IL-1β and IL-6. This study aimed to assess the relationship between peripheral inflammatory markers and psychological abnormalities in PSP-RS and PSP-P patients.
View Article and Find Full Text PDFBackground: Firefighters have a high prevalence of cardiovascular disease. The poor heart health of firefighters is implicated in their increased risk of sudden cardiac death (SCD). Exercise may be protective against SCD partially due to the immediate blood pressure (BP) reductions of 5-8 mmHg following exercise, termed postexercise hypotension (PEH) OBJECTIVES: To examine PEH under ambulatory conditions after a maximal cardiopulmonary exercise test (CPET) among career firefighters METHODS: Firefighters (n = 19) completed a maximal CPET and non-exercise control (CONTROL) in random order on separate non-workdays and left the laboratory instrumented to an ambulatory BP (ABP) monitor.
View Article and Find Full Text PDFArticle Synopsis
- Researchers are exploring the possibility of creating blood substitutes by mimicking the structure and function of hemoglobin-containing cells.
- The goal is to develop a safe and effective alternative that can provide oxygen transport in the body, similar to natural red blood cells.
- This approach could address blood supply shortages and improve medical treatment options for patients requiring transfusions.
Background: Mobile health technology's impact on cardiovascular risk factor control is not fully understood. This study evaluates the association between interaction with a mobile health application and change in cardiovascular risk factors.
Methods And Results: Participants with hypertension with or without dyslipidemia enrolled in a workplace-deployed mobile health application-based cardiovascular risk self-management program between January 2018 and December 2022.
Article Synopsis
- Multicultural older adults face greater barriers in preventive care and health disparities compared to White populations, often due to social determinants like language and transportation issues.
- This study explores an informatics-based program aimed at providing tailored microinterventions to address medication-related gaps in care for these populations through enhanced pharmacist roles.
- The analysis of claims data from a Medicare Advantage cohort (3,265 members: 78.3% Black, 21.7% Hispanic) revealed significant medication safety issues and indicated the effectiveness of multidisciplinary care coordination in improving patient outcomes.