Publications by authors named "A Zaitoun"
Article Synopsis
- Poor survival rates in periampullary cancer indicate a need for better biomarkers and new treatments.
- A study examined the protein expressions of thioredoxin (Trx), thioredoxin-interacting protein (TxNIP), and thioredoxin reductase (TrxR) in patients with pancreatic ductal adenocarcinoma (PDAC) and other related cancers using immunohistochemistry.
- Results showed that high TrxR expression was linked to lymph node metastasis, while higher Trx expression was associated with improved overall survival, highlighting the prognostic value of these proteins in periampullary cancers.
Article Synopsis
- Researchers aimed to understand the heterogeneity of pancreatic ductal adenocarcinoma by focusing on epigenetically regulated pathways that affect its progression.
- They discovered that hypermethylation of the Hepatocyte Nuclear Factor 4A (HNF4A) gene leads to its suppression, which is linked to the growth and severity of pancreatic cancer.
- The study concludes that loss of HNF4A due to DNA methylation contributes to the disease's development and is associated with worse survival outcomes for patients.
Common bile duct duplications represent exceptionally rare congenital anomalies of the biliary tract. In this case report we document an unusual variant of common bile duct duplication in a 79-year-old man who underwent a pancreaticoduodenectomy for ampullary cancer. The duplication consisted of two unseparated, completely-layered, common bile ducts which originated above the cystic duct junction and terminated prior to the point of insertion into the pancreas, where the two lumens converged into a single duct.
View Article and Find Full Text PDFBackground: The aim of this study was to establish features of inflammation in histologically normal gallbladders with gallstones and compare the expression of inflammatory markers in acutely and chronically inflamed gallbladders.
Methods: Immunohistochemistry was performed on formalin-fixed paraffin-embedded gallbladders for tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-2R, and substance p in three groups: Group I (n = 60) chronic cholecystitis, Group II (n = 57) acute cholecystitis and Group III (n = 45) histologically normal gallbladders with gallstones. Expression was quantified using the H-scoring system.
Article Synopsis
- This study compares three cytological classification systems (C1-C5, Papanicolaou, and WHO) for evaluating pancreatic neuroendocrine lesions in 73 resections over 12 years at a UK center.
- Results showed that the WHO classification had the highest accuracy in categorizing these lesions, while the Papanicolaou system excelled in differentiating neuroendocrine tumors from more aggressive forms like pancreatic adenocarcinoma.
- Overall, the study suggests that while the WHO system reduces ambiguity in malignancy classification, the Papanicolaou system provides practical management benefits without sacrificing accuracy.