Precision Cut Lung Slices: Emerging Tools for Preclinical and Translational Lung Research. An Official American Thoracic Society Workshop Report.

The urgent need for effective treatments for acute and chronic lung diseases underscores the significance of developing innovative preclinical human research tools. The 2023 ATS Workshop on Precision Cut Lung Slices (PCLS) brought together 35 experts to discuss and address the role of human tissue-derived PCLS as a unique tool for target and drug discovery and validation in pulmonary medicine. With increasing interest and usage, along with advancements in methods and technology, there is a growing need for consensus on PCLS methodology and readouts.

An Enhanced Numerical Calculation Method to Study the Anchorage Performance of Rebars.

When modelling the anchorage performance of rebars with the tri-linear law, the calculation process of the load-deformation relation is complicated. The reason is that when the rebar-grout interface entered the elastic-softening-debonding stage, the softening section length and debonding section length vary simultaneously. To solve this issue, this paper proposes an enhanced numerical calculation method.

Investigation into Effects of Coating on Stress Corrosion of Cable Bolts in Deep Underground Environments.

Due to the intricate and volatile nature of the service environment surrounding prestressing anchoring materials, stress corrosion poses a significant challenge to the sustained stability of underground reinforcement systems. Consequently, it is imperative to identify effective countermeasures against stress corrosion failure in cable bolts within deep underground environments, thereby ensuring the safety of deep resource extraction processes. In this study, the influence of various coatings on the stress corrosion resistance of cable bolts was meticulously examined and evaluated using specifically designed stress-corrosion-testing systems.

Inhibitors of SARS-CoV-2 Main Protease (Mpro) as Anti-Coronavirus Agents.

The main protease (Mpro) of SARS-CoV-2 is an essential enzyme that plays a critical part in the virus's life cycle, making it a significant target for developing antiviral drugs. The inhibition of SARS-CoV-2 Mpro has emerged as a promising approach for developing therapeutic agents to treat COVID-19. This review explores the structure of the Mpro protein and analyzes the progress made in understanding protein-ligand interactions of Mpro inhibitors.