Publications by authors named "A Zacharias"
Designing reagents for protein labeling is crucial for investigating cellular events and developing new therapeutics. Historically, much effort has been focused on labeling lysine and arginine residues due to their abundance on the protein periphery. The chemo-selectivity of these reagents is a challenging yet crucial parameter for deciphering properties specifically associated with the targeted amino acid.
View Article and Find Full Text PDFBackground: Structured rehabilitation optimizes outcomes and reduces reinjury risk after anterior cruciate ligament reconstruction (ACLR). The coronavirus 2019 (COVID-19) pandemic interrupted standard rehabilitation, possibly affecting ACLR outcomes.
Purpose: To characterize changes to ACLR functional outcomes related to the COVID-19 pandemic.
Article Synopsis
- Malaria is a serious global health issue, and understanding mosquito populations is essential for effective control, but manual mosquito identification is labor-intensive and not very practical in low-resource areas.
- Current automated methods fail to be scalable and convenient, necessitating a new solution for identifying mosquito species, sex, and abdominal status.
- The introduction of VectorBrain, a lightweight CNN-based architecture running on smartphones, has demonstrated high accuracy rates for species (94.44%), sex (97.66%), and abdominal status (82.20%), offering a promising approach to improve mosquito surveillance efforts in resource-limited settings.
Article Synopsis
- The study investigates the impact of the human milk microbiota (HMM) on the long-term health of children, particularly focusing on asthma and allergic conditions like atopy.
- Researchers followed 885 mothers and their children from birth to age 5, linking HMM composition to the mothers' genetics and children's health outcomes.
- Findings suggest that certain bacterial communities in human milk, especially decreased diversity and increased Lawsonella, are correlated with higher rates of childhood atopy and asthma, highlighting the genetic influence on HMM composition.
Background: Adults with frailty have palliative care needs [1] but have disproportionately less access to palliative care services [2]. Frailty affects ~4000 patients admitted to hospital per day in the UK [3], making the hospital admission a unique opportunity to assess palliative care needs and deliver interventions.
Objectives: Synthesise the evidence regarding hospital palliative care (HPC) for patients with frailty.