A Network Meta-Analysis of Vasodilator Therapies in Pulmonary Hypertension Patients Undergoing Mitral Valve Replacement Surgery: Insights for Optimizing Hemodynamics.

Background And Objective: Pulmonary hypertension (PH) is a progressive hemodynamic condition associated with significant morbidity and mortality, especially in patients undergoing cardiac surgery. Therefore, the objective of this network meta-analysis (NMA) is to compare the efficacy of various pulmonary vasodilators in perioperative control of PH among patients undergoing mitral valve replacement surgery (MVRS), aiming to address the existing knowledge gap and improve perioperative outcomes.

Methods: Electronic databases including PubMed, Cochrane Central Registry of Controlled Trials, Scopus, Embase, and Web of Science (WOS) from inception to 17 September 2024.

Sarecycline for moderate to severe acne: a promising narrow-spectrum antibacterial drug.

Sarecycline, a narrow-spectrum antibacterial drug approved by the FDA in 2018, targets Cutibacterium acnes while potentially minimizing disruption to the gut microbiota. The aim of this study is to assess the efficacy and safety of sarecycline compared to placebo in treating moderate to severe facial acne. A comprehensive search of PubMed, MEDLINE, and Cochrane databases was performed, with data extraction and screening conducted independently by two authors.