Publications by authors named "A Z Yan"

With the rapid development of gene editing technology, its application in breast cancer has gradually become the focus of research. This article reviews the application of gene editing technology in the treatment of breast cancer, and discusses its challenges and future development directions. The key application areas of gene editing technology in the treatment of breast cancer will be outlined, including the discovery of new therapeutic targets and the development of drugs related to the pathway.

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Karst caves are a unique environment significantly different from the external environment; adaptation of cave-dwelling animals to the cave environment is often accompanied by shifts in the sensory systems. Aquatic and terrestrial leeches have been found in the karst caves. In this study, we conducted a transcriptome analysis on the cave-dwelling leech .

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Land plants alternate between asexual sporophytes and sexual gametophytes. Unlike seed plants, ferns develop free-living gametophytes. Gametophytes of the model fern Ceratopteris exhibit two sex types: hermaphrodites with pluripotent meristems and males lacking meristems.

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Seawall construction has complex ecological impacts. However, the ecological mechanisms within plankton communities under tidal restriction resulting from seawall construction remain unexplored. Using environmental DNA (eDNA) metabarcoding, this study examined the impact of seawall construction on the assembly process of planktonic eukaryote and bacteria communities from the unrestricted area and the tide-restricted area in the Chongming Dongtan Nature Reserve of Yangtze River Estuary.

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Article Synopsis
  • Tongue swab (TS) sampling combined with quantitative PCR (qPCR) shows promise as an alternative to sputum testing for tuberculosis (TB) diagnosis, although previous studies indicated lower sensitivity.
  • Two strategies were evaluated to enhance sensitivity: one involved centrifugation to concentrate MTB DNA, achieving 83% sensitivity and 100% specificity, while the other utilized sequence-specific magnetic capture, resulting in 90% sensitivity and 97% specificity.
  • These findings suggest that with further development, these methods could lead to more accessible and effective TB testing options.
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