Publications by authors named "A Z Rabinovitz"
Background: Acute appendicitis (AA) is one of the most common indications for emergency abdominal surgery.
Objectives: To assess the diagnostic and prognostic value of serum bilirubin and liver enzyme levels in the management of acute appendicitis.
Methods: Consecutive emergency department patients referred for a surgical consult for suspected AA were prospectively enrolled in the study.
Article Synopsis
- * A study involving 635 pulmonary hypertension patients found that 27% died within a year; those with hyponatremia had a significantly higher mortality risk (HR 1.82).
- * The severity of hyponatremia was correlated with increased mortality, suggesting that monitoring sodium levels could be crucial for assessing patient outcomes in pulmonary hypertension.
Objectives: We sought to examine the association between off-label drug-eluting stent (DES) use and stent thrombosis (ST) in unselected patients undergoing percutaneous coronary intervention (PCI).
Background: DES are frequently used in clinical and angiographic scenarios not initially tested and approved by the FDA (off-label use) resulting in lingering concerns about the higher risk of ST in these situations.
Methods: Out of 5,383 patients undergoing PCI at a single center between 2004 and 2006, 380 had death or myocardial infarction within 1 year.
Treatment of cells with chemotherapy drugs activates the intrinsic mitochondrial pathway of apoptosis and the caspase protease cascade. Recently, the lysosomal protease cathepsin D has been implicated in apoptosis caused by oxidative stress, inhibition of protein kinase C, and stimulation of the TNFR1 and Fas death receptors. However, the role of cathepsin D in chemotherapy-induced cell death has remained largely unexplored.
View Article and Find Full Text PDFRecently, we reported the identification of a novel mitochondrial apoptotic pathway for granzyme B (GrB). The newly identified GrB-mediated mitochondrial cascade was initiated by the cleavage and subsequent degradation of Mcl-1, resulting in the release of mitochondrial Bim from Mcl-1 sequestration. To investigate the biological significance of Mcl-1 cleavage by GrB, we mapped the major GrB cleavage sites and evaluated the apoptotic potential of the cleavage products.
View Article and Find Full Text PDF