[Effects of ACE inhibitor fosinopril on a 24-h profile of arterial pressure in hypertensive patients with obesity and hypercholesterolemia].

Aim: To study effects of fosinopril on a 24-h profile of blood pressure (BP) in hypertensive patients with obesity and hypercholesterolemia.

Material And Methods: A randomized comparative trial enrolled 96 patients aged 30-50 years with arterial hypertension (AH) of the first and second degree. The patients were randomized into 2 groups by age, gender, AH duration, office AP, body mass index, cholesterol level.

[The antigens and nucleotide sequences of influenza A and B viruses in the lymphocytes of human peripheral blood].

Markers of influenza A and B viruses (antigens of hemagglutinin and specific nucleotide sequences) were detected in lymphocyte preparations from normal subjects. The rate of detection of the antigens and specificity (type and subtype appurtenance) of the markers correlated with the influenza epidemic situation. Lower titers of antibodies to the virus whose antigens were present in lymphocytes were observed.

[Nucleic acid molecular hybridization as a method for the laboratory diagnosis of influenza: its potentials and prospects].

Experiments carried out by the present moment in a number of laboratories indicate that the method of molecular hybridization (MH) has great diagnostic potential. Sufficient methodological mastery of the reaction of radioactively labeled DNA probes with RNA samples applied into a polymer membrane and good supply of commercially available materials make it possible to recommend this method for use in reference laboratories at specialized diagnostic centers. Hybridization should be used in combination with traditional virological and serological tests; the combined use of MH and the enzyme immunoassay for the determination of viral antigens permits the documentation of 90-98% of all cases of influenza A with sufficient rapidity.

[The results of using the molecular hybridization of nucleic acids in the complex study of nasopharyngeal smears from patients with influenza and other acute respiratory diseases].

A complex study of samples obtained from patients with influenza and other acute respiratory diseases has revealed that the laboratory methods used in this study can be rated in the following order according to their sensitivity: isolation of the virus in chick embryos, analysis of seroconversions in the hemagglutination inhibition test, immunofluorescent determination of viral antigens, determination of viral antigens by enzyme immunoassay (EIA), detection of RNA-containing viral structures by means of molecular hybridization. From the point of view of the possibility of documenting influenza A in patients, the best results are achieved by the combination of molecular hybridization and EIA techniques: 90% and more of all cases. A rational scheme for the examination of samples obtained from patients with a view to epidemiological study, including both traditional and new rapid diagnostic methods, is proposed.