Publications by authors named "A Yu Tsukanov"
Transcription factors (TFs) are the main regulators of eukaryotic gene expression. The cooperative binding of at least two TFs to genomic DNA is a major mechanism of transcription regulation. Massive analysis of the co-occurrence of overrepresented pairs of motifs for different target TFs studied in ChIP-seq experiments can clarify the mechanisms of TF cooperation.
View Article and Find Full Text PDFAs an important part of lipid metabolism the liver produces large particles called very low density lipoproteins, filled mostly with triglyceride and cholesterol esters mixture. A large percentage of the mixture composition components has a melting point above physiological temperature. Thus solid cluster formation or phase transition could be expected.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess the obstetric outcomes and urological complications related to asymptomatic bacteriuria (AB) in pregnant women using different diagnostic criteria.
- A total of 225 pregnant women participated, categorized into five groups based on their urine culture outcomes and treatment decisions, with factors like preterm birth and preeclampsia analyzed across these groups.
- Findings indicated that preterm birth was more common in all groups with AB, while preeclampsia was particularly prevalent in certain groups, though no significant differences were noted in complications such as hypertension or amnionitis.
Objective: To analyze genome-wide studies devoted to polymorphisms of factors of anterior abdominal wall hernias, to study the association of the most common polymorphism In Russian population.
Material And Methods: Searching for literature data was carried out in the RSCI and PubMed databases. We enrolled national and foreign reports.
Article Synopsis
- - Efficient motif discovery from ChIP-seq data relies heavily on selecting the right background nucleotide sequences, influencing the identification of target transcription factors and minimizing false positives from common motifs like simple sequence repeats.
- - A comparison of two methods for generating background sequences—synthetic (shuffling nucleotides) and genomic (selecting from the reference genome)—showed that the genomic approach yielded better results in detecting known motifs and reducing non-specific motifs.
- - The study implemented a web service called AntiNoise to facilitate the extraction of genomic background sequences for various eukaryotic genomes, proving particularly effective for plants when compared to mammals.