A Genome-Wide Association Study Reveals a -Centered Molecular Network Associated with Alcohol Dependence and Related Clinical Measures.

At least 50% of factors predisposing to alcohol dependence (AD) are genetic and women affected with this disorder present with more psychiatric comorbidities, probably indicating different genetic factors involved. We aimed to run a genome-wide association study (GWAS) followed by a bioinformatic functional annotation of associated genomic regions in patients with AD and eight related clinical measures. A genome-wide significant association of rs220677 with AD (-value = 1.

[Phenazepam: to the question of the efficacy and safety of benzodiazepine derivatives].

The widespread use of benzodiazepines in general medicalpractice in patients with complaints of anxiety and insomnia is due to a combination of efficacy and relative safety. Benzodiazepines have several advantages over other groups of sedatives: a wider range of doses between anxiolytic and sedative effect, a higher ratio between the average lethal and average effective doses, the lower risk of abuse. However, with prolonged use of even therapeutic doses of benzodiazepines (more than 6 months), the risk of dependence may increase - more often with the use of high-potency short-acting drugs.

[The efficacy of remaxol addition in the treatment of alcohol withdrawal syndrome].

Objective: To study the efficacy of remaxol addition in the treatment scheme of alcohol withdrawal syndrome.

Material And Methods: Eighty patients with alcohol dependence and physical symptoms of alcohol withdrawal syndrome were enrolled. All patients received basic therapy in accordance to the applicable standards of treatment.