Economical droplet-based microfluidic production of [F]FET and [F]Florbetaben suitable for human use.

Current equipment and methods for preparation of radiopharmaceuticals for positron emission tomography (PET) are expensive and best suited for large-scale multi-doses batches. Microfluidic radiosynthesizers have been shown to provide an economic approach to synthesize these compounds in smaller quantities, but can also be scaled to clinically-relevant levels. Batch microfluidic approaches, in particular, offer significant reduction in system size and reagent consumption.

A simplified cluster model and a tool adapted for collaborative labeling of lung cancer CT scans.

Background And Objective: Lung cancer is the most common type of cancer with a high mortality rate. Early detection using medical imaging is critically important for the long-term survival of the patients. Computer-aided diagnosis (CAD) tools can potentially reduce the number of incorrect interpretations of medical image data by radiologists.

Membrane-Introduction Mass Spectrometry Analysis of Desflurane, Propofol and Fentanyl in Plasma and Cerebrospinal Fluid for Estimation BBB Properties.

A possibility to use the Membrane-Introduction Mass Spectrometry (MIMS) with membrane separator interface has evolved into a powerful method for measurement of anaesthetic agents absolute concentration in blood plasma and cerebrospinal fluid for the study of blood-brain barrier (BBB) properties. Recent advanced a new membrane material was used for drug concentration measurement in biologic fluids. A hydrophobic membrane was used in the interface to separate anaesthetic agents from biological fluids: inhalational anaesthetic desflurane,hypnotic propofol, analgesic fentanyl.

[Mass-spectrometric control of compound A during minimal flow anesthesia and its influence on liver and kidneys functions].

The article contains results of mass-spectrometric control of sevoflurane and compound A concentrations during inhalation anesthesia with minimal flow (< or = 0.5 l/min) and its influence on liver and kidney function. 40 patients (ASA I-II) were included in the study.

Mass-spectrometric monitoring of anesthesia adequacy.

Anesthesia adequacy was assessed with mass-spectrometric method by monitoring the ratio of mass concentrations of end-tidal CO2 and inhaled O2 in every respiratory cycle during surgery. For real-time monitoring, we used a mass spectrometer with electron ionization connected to the respiratory contour of inhalation anesthesia machine. The study has demonstrated advantages of the novel method in real-time assessment of adequacy of the total intravenous anesthesia.