Publications by authors named "A Yu Anisenkova"
Severe course of COVID-19 is largely determined by hyperactivation of the immune system, or cytokine storm, in which immune cells (lymphocytes, monocytes, etc.) play a major role. Using low-voltage scanning electron microscopy, we studied the morphology of lymphocytes and monocytes during cytokine storm.
View Article and Find Full Text PDFSevere COVID-19 alters the biochemical and morphological characteristics of blood cells in a wide variety of ways. To date, however, the vast majority of research has been devoted to the study of leukocytes, while erythrocyte morphological changes have received significantly less attention. The aim of this research was to identify erythrocyte morphology abnormalities that occur in COVID-19, compare the number of different poikilocyte types, and measure erythrocyte sizes to provide data on size dispersion.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the genetic factors influencing COVID-19 severity using a cohort of 840 patients from Russia, aiming to address challenges of cohort size and genome coverage in previous research.
- While no significant gene or pathway-level associations were found, the researchers identified eleven candidate loci linked to various quantitative traits in COVID-19 patients.
- Notably, a risk score derived from certain genetic variants was able to predict hospitalization severity and outcomes, showcasing the potential of using quantitative traits for identifying genetic risk factors in COVID-19 research.
Objective: A critical role in coronavirus disease 2019 (COVID-19) pathogenesis is played by immune dysregulation that leads to a generalized uncontrolled multisystem inflammatory response, caused by overproduction of proinflammatory cytokines, known as "a cytokine storm" (CS), strongly associated with a severe course of disease. The aim of this study is to identify prognostic biomarkers for CS development in COVID-19 patients and integrate them into a prognostic score for CS-associated risk applicable to routine clinical practice.
Materials And Methods: The authors performed a review of 458 medical records from COVID-19 patients (241 men and 217 women aged 60.
Article Synopsis
- The study investigates the role of genetic variants in the susceptibility and severity of COVID-19 using a large dataset (gnomAD) and a group of 37 Russian patients.
- It finds slight differences in allele frequencies among European populations, particularly noting that Southern Europeans have fewer missense variants.
- While common genetic variants do not significantly impact COVID-19 severity, some rare variants may influence disease outcomes, suggesting genetics play a role in varying COVID-19 severity.