Publications by authors named "A Yoshizawa"
Activation of thyroid-stimulating hormone receptor (TSHR) fundamentally leads to hyperthyroidism. To elucidate TSHR signaling, we conducted transcriptome analyses for hyperthyroid mice that we generated by overexpressing TSH. TSH overexpression drastically changed their thyroid transcriptome.
View Article and Find Full Text PDFLung Transplantation for Familial Diffuse Pulmonary Ossification.
Ann Thorac Surg Short Rep
September 2024
We report 3 cases of extremely rare familial idiopathic diffuse pulmonary ossification, 2 of 3 received lung transplantation and the other is listed for lung transplantation. The clinical courses of family members varied greatly, and rapid deterioration could occur; therefore, early and close examination is recommended for transplant registration. During transplantation, the lungs appeared and felt exactly like a "pumice stone" and could not collapse, and good visual field was not easily obtained.
View Article and Find Full Text PDFBackground: The composite physiologic index (CPI) was developed to estimate the extent of interstitial lung disease (ILD) in idiopathic pulmonary fibrosis (IPF) patients based on pulmonary function tests (PFTs). The CALIPER-revised version of the CPI (CALIPER-CPI) was also developed to estimate the volume fraction of ILD measured by CALIPER, an automated quantitative CT postprocessing software. Recently, artificial intelligence-based quantitative CT image analysis software (AIQCT), which can be used to quantify the bronchial volume separately from the ILD volume, was developed and validated in IPF.
View Article and Find Full Text PDFArticle Synopsis
- Fibroblastic foci (FF) are important indicators of usual interstitial pneumonia (UIP) but can also appear in various fibrotic interstitial lung diseases (ILDs), making them non-specific for UIP.
- This study analyzed the spatial distribution of FF in different forms of ILDs in patients who underwent lung transplants, categorizing them by anatomical location.
- Results showed that idiopathic pulmonary fibrosis (IPF) had more total and peripheral FF compared to other ILDs, while centrilobular FF was more prevalent in fibrotic hypersensitivity pneumonitis (FHP), suggesting distinct spatial patterns associated with different diseases.
Article Synopsis
- Erdheim-Chester disease (ECD) is a rare condition involving abnormal cell growth, characterized by specific types of histiocytes and granulomas leading to tissue fibrosis.
- About 50% of ECD patients show cardiovascular issues on imaging, but detailed pathological findings are not widely reported.
- An autopsy of an ECD patient revealed a link between arterial blockages and a BRAF gene mutation, suggesting the need to investigate BRAF mutations in ECD patients with arterial complications.