Opioid withdrawal syndrome induced by naldemedine administration in a cancer patient without brain metastasis.

Objectives: Naldemedine is a peripherally acting μ-opioid receptor antagonist used to treat opioid-induced constipation. As this drug does not cross the blood-brain barrier, it is believed that patients without brain metastases do not experience opioid withdrawal symptoms.

Methods: Here, we experienced a case in which a cancer patient without brain metastasis presented with anxiety and restlessness that was severe enough to interfere with daily life.

Gaze cues facilitate incidental learning in children aged 7-10 years, but arrow cues do not.

From infancy, humans use gaze cues from others to learn about their surrounding environment. It is known that gaze cues facilitate the cognitive processing of targets in both infants and adults, but what developmental changes occur during childhood? This study investigated the impact of gaze cueing on incidental learning in children aged 7-10 years (n = 80). Participants completed a cueing task where they were presented with gaze or arrow cues (valid or invalid) followed by a target stimulus.

Tri-specific tribodies targeting 5T4, CD3, and immune checkpoint drive stronger functional T-cell responses than combinations of antibody therapeutics.

One of the most promising cancer immunotherapies is based on bi-specific T-cell engagers (BiTEs) that simultaneously bind with one arm to a tumor-associated antigen on tumor cells and with the other one to CD3 complex on T cells to form a TCR-MHC independent immune synapse. We previously generated four novel tri-specific tribodies made up of a Fab targeting 5T4, an oncofetal tumor antigen expressed on several types of tumors, a scFv targeting CD3 on T cells, and an additional scFv specific for an immune checkpoint (IC), such as PD-1, PD-L1 or LAG-3. To verify their advantages over the combinations of BiTEs (CD3/TAA) with IC inhibitors, recently used to overcome tumor immunosuppressive environment, here we tested their functional properties in comparison with clinically validated mAbs targeting the same ICs, used alone or in combination with a control bi-specific devoid of immunomodulatory scFvs, called 53 P.

Evaluation of Coagulation and Fibrinolysis Mechanisms in Deep Vein Thrombosis Using Clot-Fibrinolysis Waveform Analysis.

Introduction: Deep vein thrombosis (DVT) is a common condition associated with significant morbidity and mortality. However, the detailed mechanisms of coagulation and fibrinolysis in DVT have not been adequately investigated. Recently, clot-fibrinolysis waveform analysis (CFWA) has been developed to assess coagulation and fibrinolysis reactions as one global assay.

The diagnostic utility of intima-media thickness measurement compared with the halo sign in temporal artery ultrasonography: a single-centre retrospective study.

Objectives: We aimed to examine the diagnostic utility of temporal artery ultrasonography (TAUS) based on measurement of intima-media thickness (IMT) compared with the halo sign in diagnosing cranial giant cell arteritis (GCA).

Methods: We retrospectively analysed consecutive patients with clinically suspected GCA who had undergone TAUS between January 2011 and December 2021 in Tenri hospital, Japan. A cut-off value of 0.