Adsorption of hexavalent chromium using Water Hyacinth Leaf Protein Concentrate/Graphene Oxide hydrogel.

Water Hyacinth Leaf Protein Concentrate/Graphene Oxide (WHLPC/GO) hydrogel was synthesized for the removal of Cr(VI) from wastewater. About 90% of the prepared hydrogel constitutes WHLPC. The prepared material was characterized by FT-IR and XRD.

Cheap and sensitive polymer/bismuth film modified electrode for simultaneous determination of Pb(II) and Cd(II) ions.

Different aminonaphetalenesulphonic acid derivatives like 5-aminonaphthalene-1-sulphonic acid (5AN1SA), 2-aminonaphthalene-1-sulphonic acid (2AN1SA), 8-aminonaphthalene-2-sulphonic acid (8AN2SA) and 4-amino-3-hydroxynaphthalene-1-sulphonic acid (4A3HN1SA) were used to construct polymer/bismuth film modified electrode for simultaneous determination of Pb(II) and Cd(II) ions with the aim of developing a cheaper and sensitive electrode that could possibly replace Nafion. Among the different modified electrodes, poly (8AN2SA)/bismuth film modified electrodes showed the highest electrochemical response for both ions. These electrochemical results were also supported by density functional theory (DFT) calculations.

Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.

Herein, we describe the discovery and optimization of a novel series that inhibits bacterial DNA gyrase and topoisomerase IV binding to, and stabilization of, DNA cleavage complexes. Optimization of this series led to the identification of compound , which has potent activity against Gram-positive bacteria, a favorable safety profile, and excellent pharmacokinetic properties. Compound was found to be efficacious against fluoroquinolone-sensitive infection in a mouse thigh model at lower doses than moxifloxacin.

Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline.

This report summarizes the identification and synthesis of novel LpxC inhibitors aided by computational methods that leveraged numerous crystal structures. This effort led to the identification of oxazolidinone and isoxazoline inhibitors with potent in vitro activity against P. aeruginosa and other Gram-negative bacteria.

Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.

Metallo-β-lactamases (MBLs), such as New Delhi metallo-β-lactamase (NDM-1) have spread world-wide and present a serious threat. Expression of MBLs confers resistance in Gram-negative bacteria to all classes of β-lactam antibiotics, with the exception of monobactams, which are intrinsically stable to MBLs. However, existing first generation monobactam drugs like aztreonam have limited clinical utility against MBL-expressing strains because they are impacted by serine β-lactamases (SBLs), which are often co-expressed in clinical isolates.