Publications by authors named "A Yatani"
Article Synopsis
- A new portable oxygen concentrator with an auto-demand oxygen delivery system (auto-DODS) adjusts its oxygen supply based on inhalation needs, providing oxygen only during inhalation rather than continuously.
- This study aimed to compare the effectiveness and safety of the auto-DODS system against a continuous flow oxygen concentrator for patients using home oxygen therapy while sleeping, using a randomized crossover trial design.
- Results indicated that the auto-DODS maintained oxygen saturation levels almost identically to the continuous flow system, with only a 0.835% difference, well within the acceptable safety margin, and no adverse effects were reported during the trial.
Background: Next-generation sequencing (NGS) is essential for lung cancer treatment. It is important to collect sufficient tissue specimens, but sometimes we cannot obtain large enough samples for NGS analysis. We investigated the yield of NGS analysis by frozen cytology pellets using an Oncomine Comprehensive Assay or Oncomine Precision Assay.
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- - The study investigates how concurrent drug use, specifically antibiotics, proton pump inhibitors (PPIs), and NSAIDs, affects the outcomes of immunotherapy in patients with advanced non-small cell lung carcinoma (NSCLC).
- - Analysis of 127 patients revealed no significant impact from antibiotics, but those using NSAIDs had noticeably worse treatment responses and survival rates compared to non-users.
- - The findings suggest that using NSAIDs during immunotherapy could hinder treatment effectiveness, indicating that their unnecessary use should be avoided.
HIP1-ALK is a relatively rare fusion pattern in ALK-rearranged NSCLC. Existing studies on the efficacy of ALK tyrosine kinase inhibitor (TKI) resistance mechanisms and treatment strategies in HIP1-ALK-rearranged lung cancer are limited. Here, we report the case of an 18-year-old man with HIP1-ALK-rearranged adenocarcinoma who developed BRAF V600E and V1180L mutations after ALK TKI therapy, in whom the administration of BRAF and MEK inhibitors was ineffective.
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- Ultrathin bronchoscopy shows a higher diagnostic yield for small peripheral lung lesions compared to thin bronchoscopy, but the difference in the number of tumor cells in non-small cell lung cancer (NSCLC) remains unclear.
- A study analyzed data from 175 patients, comparing tumor cell counts from NSCLC lesions using both types of bronchoscopes; the ultrathin group had smaller lesions but similar diagnostic yields.
- Results indicated no significant differences in maximum tumor cell counts or success rates of genetic analysis between the two techniques, suggesting similar effectiveness for NSCLC sample collection.