In the veterinary field, the utility of disease-identification models that use comprehensive circulating microRNA (miRNA) profiles produced through measurements based on next-generation sequencing (NGS) remains unproven. To integrate NGS technology with automated machine learning (autoML) to create a comprehensive circulating miRNA profile and to assess the clinical utility of a disease-screening model derived from this profile. The study involved dogs diagnosed with or being treated for various diseases, including tumors, across multiple veterinary clinics ( = 254), and healthy dogs without apparent diseases ( = 91).
View Article and Find Full Text PDFNon-tuberculous mycobacteriosis (NTM) is a rare infection that can manifest as pulmonary, disseminated, or cutaneous disease. Cutaneous NTM infections are often associated with immunosuppressive conditions, such as HIV infection or exposure to contaminated water, but they can also occur in healthy individuals, complicating the diagnosis. We report the case of a 54-year-old male with a gradually enlarging skin ulcer on his left upper limb.
View Article and Find Full Text PDFBackground & Aims: Reduced muscle mass is one of the diagnostic components for Global Leadership Initiative on Malnutrition (GLIM), with various assessment methods proposed. Calf circumference (CC), a representative anthropometric marker of skeletal muscle mass, is now recommended to adjustment based on body mass index (BMI). This study aimed to evaluate the validity and efficacy of BMI-adjusted CC in very older adults, compared with other methods of assessing muscle mass.
View Article and Find Full Text PDFIntroduction: This study aimed to evaluate the efficacy of perioperative dysphagia rehabilitation in older adult patients diagnosed with gastric cancer who underwent gastrectomy.
Materials And Methods: This retrospective study included 149 patients over 80 years who underwent gastrectomies between January 2000 and December 2020. The patients were divided into two groups based on the intervention of the dysphagia rehabilitation team (DRT group: n = 101) and the non-intervention control group (C group: n = 48).