Procalcitonin level threshold and antibiotic use in patients receiving chimeric antigen receptor T-cell therapy.

Background: Patients undergoing chimeric antigen receptor (CAR) T-cell therapy are vulnerable to infection and sepsis. Treatment course is frequently complicated by cytokine release syndrome which is often clinically and biochemically indistinguishable from sepsis. Procalcitonin (PCT) levels have been examined as a promising biomarker for infection in this cohort of patients.

Massive lignocaine overdose while on veno-arterial extracorporeal membrane oxygenation (VA ECMO).

We present the extraordinary circumstance of a female patient in her sixties who suffered a massive lignocaine overdose while undergoing treatment with Veno-Arterial Extracorporeal Membrane Oxygenation (VA ECMO) following an emergency coronary artery bypass graft (CABG). The patient was initially admitted to the Intensive Care Unit (ICU) due to unstable angina and a history of insulin-dependent type two diabetes mellitus, hypertension, hypercholesterolemia, carotid artery stenosis, and an extensive smoking history. Despite initial improvements following surgery, she experienced repeated episodes of nonsustained polymorphic ventricular tachycardia (VT) that were refractory to conventional antiarrhythmic medications.

How Rigidity and Conjugation of Bidentate Ligands Affect the Geometry and Photophysics of Iron -Heterocyclic Complexes: A Comparative Study.

Two iron complexes featuring the bidentate, nonconjugated N-heterocyclic carbene (NHC) 1,1'-methylenebis(3-methylimidazol-2-ylidene) (mbmi) ligand, where the two NHC moieties are separated by a methylene bridge, have been synthesized to exploit the combined influence of geometric and electronic effects on the ground- and excited-state properties of homoleptic Fe-hexa-NHC [Fe(mbmi)](PF) and heteroleptic Fe-tetra-NHC [Fe(mbmi)(bpy)](PF) (bpy = 2,2'-bipyridine) complexes. They are compared to the reported Fe-hexa-NHC [Fe(btz)](PF) and Fe-tetra-NHC [Fe(btz)(bpy)](PF) complexes containing the conjugated, bidentate mesoionic NHC ligand 3,3'-dimethyl-1,1'-bis(-tolyl)-4,4'-bis(1,2,3-triazol-5-ylidene) (btz). The observed geometries of [Fe(mbmi)](PF) and [Fe(mbmi)(bpy)](PF) are evaluated through L-Fe-L bond angles and ligand planarity and compared to those of [Fe(btz)](PF) and [Fe(btz)(bpy)](PF).