Publications by authors named "A Yanagida"
Sox17 is a key transcriptional regulator of endoderm formation and function in the gallbladder, blood vessels and reproductive organs. Although multiple transcript variants of Sox17 have been suggested, the precise mechanisms underlying their time- and tissue-specific expression remain unclear. In this study, we discovered two putative regulatory sequences (R1 and R2) adjacent to different transcription start sites of mouse Sox17 exon 1 and generated deletion mice for these regions (Sox17).
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- - Medication adherence is crucial for effective treatment in chronic diseases, particularly cardiovascular diseases (CVDs), and this study aimed to assess adherence using both subjective (self-reported surveys) and objective (pill counting) methods among outpatients from Fukuoka University Chikushi Hospital.
- - The study involved 94 patients and found no significant differences in adherence when comparing subjective survey scores with objective pill counting results, highlighting a discrepancy between how patients perceive their adherence and actual medication-taking behavior.
- - A multivariate analysis identified obesity as a significant factor linked to poor medication adherence, suggesting that healthcare providers should pay extra attention to patients with CVD who are also obese.
Article Synopsis
- Mammalian embryos form blastocysts with a trophectoderm (TE) layer and an inner cell mass (ICM), which are essential for implantation, differing by species.
- Murine embryos have a single-layered TE until they implant, while human blastocysts attach directly to the uterine wall with a unique TE structure.
- Research shows human TE may multi-layer before implantation, crucial for securing the embryo and starting placenta formation, with most inner TE cells originating from the outer TE rather than the ICM.
Background: Biliary atresia (BA) is an intractable disease of unknown cause that develops in the neonatal period. It causes jaundice and liver damage due to the destruction of extrahepatic biliary tracts,. We have found that heterozygous knockout mice of the SRY related HMG-box 17 (Sox17) gene, a master regulator of stem/progenitor cells in the gallbladder wall, exhibit a condition like BA.
View Article and Find Full Text PDFAutologous skin grafting is a standard treatment for skin defects such as burns. No artificial skin substitutes are functionally equivalent to autologous skin grafts. The cultured epidermis lacks the dermis and does not engraft deep wounds.
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