Publications by authors named "A Yamashita"
A 63-year-old woman undergoing peritoneal dialysis (PD) presented to our hospital with abdominal pain, diarrhea, and cloudy PD effluent. An elevated white blood cell count in the PD effluent led to a diagnosis of PD-associated peritonitis. She was subsequently started on intraperitoneal cefazolin and ceftazidime, after which her condition improved rapidly.
View Article and Find Full Text PDFA 46-year-old woman on peritoneal dialysis (PD) had cloudy peritoneal dialysis effluent that had persisted for 10 days by the time she visited our hospital. The white blood cell count in the effluent was elevated to 1500/μL, leading to a diagnosis of peritoneal dialysis-associated peritonitis. The effluent cleared within two days with treatment using cefazolin and ceftazidime, and the white blood cell count dropped to 0/μL by day 6.
View Article and Find Full Text PDFJNJ-75220795 or ARO-PNPLA3 is an investigational small interfering ribonucleic acid agent conjugated with N-acetyl-d-galactosamine that targets the PNPLA3 gene, currently being developed for metabolic dysfunction-associated steatohepatitis (MASH). This study evaluated the pharmacokinetics (PK) profile of single subcutaneous doses of JNJ-75220795 in preclinical species as well as in human subjects with homozygous or heterozygous PNPLA3 I148M mutation in two phase 1 studies-a first-in-human study in the United States and a first-in-Japanese study in Japan. Preclinical PK in rats and non-human primates (NHP) showed a rapid systemic absorption and elimination following single subcutaneous doses.
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- Current HPV vaccines protect against specific types but have limited effectiveness against other HPV strains, highlighting the need for a broader vaccine approach.
- This study developed a multivalent L2-based mRNA vaccine targeting prevalent HPV types and evaluated its performance in mice using different delivery methods.
- The results showed that the new vaccine induced strong immune responses and provided cross-protection against both targeted and non-targeted HPV types, suggesting it could significantly reduce HPV-related cancers globally.
Peritoneal dialysis (PD)-associated peritonitis is a serious complication of PD, and its prevention and treatment are important for reducing patient morbidity and mortality. Reports of PD-associated peritonitis caused by Corynebacterium spp. are limited, and PD-associated peritonitis caused by Corynebacterium striatum (C.
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