Publications by authors named "A Yamashina"
Article Synopsis
- The HEART study examined the effects of eplerenone, a mineralocorticoid receptor antagonist, in patients hospitalized for acute heart failure (HF) over 6 months, highlighting concerns about potential adverse events like worsening renal function and hyperkalemia.
- Among 297 participants, notable adverse events were recorded, but eplerenone did not significantly raise their occurrence compared to placebo, suggesting it is a safe option for HF treatment.
- Certain patient characteristics, such as older age and existing health conditions, were linked to a higher risk of adverse events, but these factors did not diminish the benefits of eplerenone on overall outcomes.
Heart-brachium pulse wave velocity (hbPWV) is a promising measure of arterial stiffness including the proximal aorta. To characterize age-associated changes and the clinical utilities of hbPWV, we evaluated the impacts of age and cardiovascular disease (CVD) risks on hbPWV cross-sectionally (N = 7868) and longitudinally (N = 3710, followed by 9.1 ± 2.
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- - The study aimed to understand how serum small dense low-density lipoprotein cholesterol (sdLDL-C) and triglyceride (TG) levels relate to cardiovascular events in patients with coronary artery disease (CAD) and type 2 diabetes who are on statins.
- - Participants were categorized into four groups based on their sdLDL-C and TG levels, with cardiovascular events tracked over a median of 1419 days, resulting in 34 events during the study.
- - Results indicated that patients with sdLDL-C levels of 40.0 mg/dL or higher faced a greater risk of cardiovascular events, even when their TG levels were below 150 mg/dL, highlighting the residual risk present despite statin treatment.
Aims: In the arterial tree, a pressure gradient of the systolic blood pressure (SBP) is observed from the center to the periphery, with the pressure being higher in the periphery because of pressure wave reflection. However, this gradient is attenuated, with elevation of the central SBP (cSBP), in cases with abnormal pressure wave reflection in the arterial tree. It remains unclear if increase of the cSBP might be an independent risk factor for accelerated progression of arterial stiffness.
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