Pregnane C21-Steroids with Anti-inflammatory Activity from the Roots of Cynanchum bungei.

Five pregnane C21-steroids, including three 5,6-epoxy steroids (1-3) and two 8,14-seco-steroids (4 and 5), were isolated from the acid hydrolysate of Cynanchum bungei roots. Cynbungenins L-O (1-4) are previously undescribed compounds. Compound 3 with a 5a,6a-epoxy group represents the first example found in the Cynanchum plants.

Text-guided small molecule generation via diffusion model.

The generation of molecules with targeted properties is crucial in biology, chemistry, and drug discovery. Current generative models are limited to using single property values as conditions, struggling with complex customizations described in detailed human language. To address this, we propose the text guidance instead, and introduce TextSMOG, a new via , which integrates language and diffusion models for text-guided small molecule generation.

Circle Padlock-Mediated Catalytic Hairpin Assembly Cooperating Primer Exchange Reaction for Sensitive and Label-Free MicroRNA Detection.

MicroRNAs (miRNAs), which play critical roles in regulating gene expression and cell functions, are recognized as potential biomarkers for various human diseases, including gastric ulcers. The reliable, specific, and sensitive detection of miRNA is highly recommended for the clinical diagnosis and therapy of different diseases. Herein, we depict a label-free and low-background fluorescent assay for the highly sensitive detection of miRNAs by coupling target miRNA-triggered cyclization of a padlock, circular padlock-mediated catalytic hairpin assembly (CHA), and primer exchange reaction (PER)-assisted signal generation.

A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analysis.

Objectives: The study will evaluate the effectiveness and safety of finerenone in patients diagnosed with diabetic kidney disease (DKD).

Methods: Various databases including PubMed, Sinomed, Web of Science, Embase, Clinical Trials, and Cochrane Library were systematically reviewed for pertinent studies published from the beginning to February 2024.This meta-analysis utilized RevMan 5.

MAX phase coatings: synthesis, protective performance, and functional characteristics.

MAX (MAX) phases are a novel class of materials with a closely packed hexagonal structure that bridge the gap between metals and ceramics, garnering tremendous research interest worldwide in recent years. Benefiting from their unique layered structure and mixed covalent-ionic-metallic bonding characteristics, MAX phase coatings possess excellent oxidation resistance, and exceptional electrical and thermal conductivities, making them highly promising for applications in advanced nuclear materials, battery plate protection materials, and aero-engine functional materials. This review aims to provide a comprehensive understanding of MAX phase coatings.