Publications by authors named "A Y Yakovlev"

The optimization in the ambulance dispatching process is significant for patients who need early treatments. However, the problem of dynamic ambulance redeployment for destination hospital selection has rarely been investigated. The paper proposes an approach to model and simulate the ambulance dispatching process in multi-agent healthcare environments of large cities.

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The increasing demand for processing large volumes of data for machine learning (ML) models has pushed data bandwidth requirements beyond the capability of traditional von Neumann architecture. In-memory computing (IMC) has recently emerged as a promising solution to address this gap by enabling distributed data storage and processing at the micro-architectural level, significantly reducing both latency and energy. In this article, we present In-Memory comPuting architecture based on Y-FlAsh technology for Coalesced Tsetlin machine inference (IMPACT), underpinned on a cutting-edge memory device, Y-Flash, fabricated on a 180 nm complementary metal oxide semiconductor (CMOS) process.

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Article Synopsis
  • * Research indicates that exposure to psychoactive substances affects the production and composition of sEVs, with potential differences based on sex.
  • * The study suggests there are two mechanisms through which psychoactive substances impact sEVs: a "fast" mechanism that promotes neuroplasticity, and a "slow" mechanism that disrupts the normal production of sEVs.
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  • Hyperhomocysteinemia (hHCY) is linked to increased plasma homocysteine levels and correlates with a higher risk of migraines, especially those with aura.
  • The study investigated how hHCY affects cortical spreading depression (CSD) and neuronal activity in the somatosensory cortex of rats, highlighting an increased excitability and more frequent CSDs in those with hHCY.
  • Results showed impaired CSD propagation and delayed recovery of brain activity in hHCY animals, indicating that prolonged high homocysteine levels may increase the risk of migraine-associated brain injuries.
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A dynamic study of ceramide concentrations and their association with recurrent event risk could enhance our understanding of cardiovascular complications. To assess the prognostic value of ceramide concentrations (Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:1), Cer(d18:1/24:0)) and their dynamics in combination with standard clinical and laboratory parameters and therapeutic interventions in ACS patients. Among 110 ACS patients, triple blood sampling was performed for targeted lipidomic analysis using high-performance liquid chromatography-tandem mass spectrometry.

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