Publications by authors named "A Y Tokmakova"

Age-related impairment of the diaphragm causes respiratory complications. Neuromuscular junction (NMJ) dysfunction can be one of the triggering events in diaphragm weaknesses in old age. Prominent structural and functional alterations in diaphragm NMJs were described in elderly rodents, but NMJ changes in middle age remain unclear.

View Article and Find Full Text PDF
Article Synopsis
  • Diabetic foot ulcers (DFUs) are serious complications of type 2 diabetes, leading to chronic skin ulcers that are difficult and costly to treat; early prediction could help mitigate these issues.
  • A study conducted on diabetic patients in the Moscow region evaluated genetic markers (SNPs) linked to DFUs, but results failed to confirm many previous associations.
  • Interestingly, a specific variant in the TCF7l2 gene, which is a known type 2 diabetes risk factor, appeared to have a protective effect against DFUs, hinting at the potential complexity of genetic influences versus environmental factors.
View Article and Find Full Text PDF

Many bacterial plant pathogens have a broad host range important for their life cycle. Alternate hosts from plant families other than the main (primary) host support the survival and dissemination of the pathogen population even in absence of main host plants. Metabolic peculiarities of main and alternative host plants can affect genetic diversity within and between the pathogen populations isolated from those plants.

View Article and Find Full Text PDF

The 25 human bitter taste receptors (TAS2Rs) are expressed on taste and extra-oral cells representing an integrated chemosensory system. The archetypal TAS2R14 is activated by > 150 topographically diverse agonists, raising the question of how this uncharacteristic accommodation is achieved for these GPCRs. We report the computationally derived structure of TAS2R14 with binding sites and energies for five highly diverse agonists.

View Article and Find Full Text PDF

is one of the most important genera of phytopathogenic bacteria. It can cause soft-rot diseases on a wide range of plant species across the world. In this study, three strains (KC01, KC02, and KC03) were isolated from soft-rotted Chinese cabbage in Beijing, China.

View Article and Find Full Text PDF