Identifying key genes in cancer networks using persistent homology.

Identifying driver genes is crucial for understanding oncogenesis and developing targeted cancer therapies. Driver discovery methods using protein or pathway networks rely on traditional network science measures, focusing on nodes, edges, or community metrics. These methods can overlook the high-dimensional interactions that cancer genes have within cancer networks.

Effects of growth hormone replacement therapy in childhood-onset craniopharyngioma: an updated systematic review and meta-analysis.

Purpose: Craniopharyngiomas (CPs) often lead to growth hormone deficiency (GHD) in children. Growth hormone replacement therapy (GHRT) is essential for managing GHD but its impact on body mass index (BMI) and metabolic outcomes is controversial. Concerns exist that GHRT might contribute to tumor recurrence, with guidelines varying on when to start therapy post-surgery.

Effects of periodontal disease on the reproductive performance and offspring of Wistar rats.

Background: Periodontitis can induce systemic inflammation, and it may affect the testicles and male reproductive performance. This study investigated the effects of periodontitis on the testicles, reproductive performance, and offspring development in male rats.

Methods: Male Wistar rats were induced with periodontitis by ligating their first molars.

Effects of strength training with free weights and elastic resistance in older adults: A randomised clinical study.

Background: The aging process leads to negative changes in various bodily systems, including the neuromuscular system. Strength training, is considered the best strategy to counteract these neuromuscular changes, preventing sarcopenia and frailty in older adults.

Objective: To compare the effects of strength training with elastic resistance and free weights on the muscle strength of knee extensors and flexors and functional performance in the older adults.

Systemic acupuncture application does not change muscle performance parameters in women: A randomized, controlled, double-blind pilot study.

Background/objective: Acupuncture is used for therapeutic purposes. The possible beneficial role of this therapy may be as an ergogenic resource for the performance of fitness variables in exercise and sports. To date, acupuncture has been associated with increases in muscle strength, aerobic power, and vertical jump performance, but the evidence is still inconclusive.