Publications by authors named "A Y Shanab"
Biofilms formed by several bacterial strains still pose a significant challenge to healthcare due to their resistance to conventional treatment approaches, including antibiotics. This study explores the potential of loading natural extracts with antimicrobial activities into β-cyclodextrin (βCD) nanoparticles, which are FDA-approved and have superior biocompatibility owing to their cyclic sugar structures, for biofilm eradication. An inclusion complex of βCD carrying essential oils (BOS) was prepared and characterized with regard to its physicochemical properties, antimicrobial efficacy, and antibiofilm activities.
View Article and Find Full Text PDFArticle Synopsis
- The human amniotic membrane (hAM) serves as an effective scaffold in tissue engineering, enhancing the survival and regenerative abilities of mesenchymal stromal cells (MSCs) when cultured in a 3D environment.
- Adipose-derived MSCs (AMSCs) showed increased cell viability, proliferation, and expression of key MSC markers, along with changes in pro-angiogenic and inflammatory markers, leading to improved differentiation potential.
- Metabolic analysis revealed that hAM scaffold upregulated glycolysis and altered mitochondrial function in MSCs, suggesting its potential as a biomimetic scaffold to boost MSC functionality for clinical applications.
T lymphocytes play a primary role in the adaptive antiviral immunity. Both lymphocytosis and lymphopenia were found to be associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While lymphocytosis indicates an active anti-viral response, lymphopenia is a sign of poor prognosis.
View Article and Find Full Text PDFMeningitis, an infection of the meninges of the central nervous system (CNS), can advance quickly and carries a mortality rate reaching 30% among affected patients. It may become complicated by conditions such as hydrocephalus, ventriculitis, and cerebral abscess. Here, we describe a case of meningitis that was complicated by pyogenic ventriculitis and hydrocephalus in a patient with diffuse large B-cell lymphoma (DLBCL) who underwent chemotherapy and radiotherapy.
View Article and Find Full Text PDFNeuroblastoma (NB) is one of the leading causes of cancer-associated death in children. MYCN amplification is a prominent genetic marker for NB, and its targeting to halt NB progression is difficult to achieve. Therefore, an in-depth understanding of the molecular interactome of NB is needed to improve treatment outcomes.
View Article and Find Full Text PDF