In utero exposure to experimental maternal asthma alters fetal airway development in sheep.

The mechanisms linking maternal asthma (MA) exposure in utero and subsequent risk of asthma in childhood are not fully understood. Pathological airway remodelling, including reticular basement membrane thickening, has been reported in infants and children who go on to develop asthma later in childhood. This suggests altered airway development before birth as a mechanism underlying increased risk of asthma in children exposed in utero to MA.

Radiobiologically equivalent deformable dose mapping for re-irradiation Planning: Implementation, Robustness, and dosimetric benefits.

Background: Re-irradiation in radiotherapy presents complexities that require dedicated tools to generate optimal re-treatment plans. This study presents a robust workflow that considers fractionation size, anatomical variations between treatments, and cumulative bias doses to improve the re-irradiation planning process.

Methods: The workflow was automated in MIM® Software and the Elekta© Monaco® treatment planning system.

Prediction of pre-eclampsia using maternal hemodynamic parameters at 12 + 0 to 15 + 6 weeks.

Objectives: To compare the maternal hemodynamic profile at 12 + 0 to 15 + 6 weeks' gestation in women who subsequently developed pre-eclampsia (PE) and those who did not, and to assess the screening performance of maternal hemodynamic parameters for PE in combination with the Fetal Medicine Foundation (FMF) triple test, including maternal factors (MF), mean arterial pressure (MAP), uterine artery pulsatility index and placental growth factor.

Methods: This was a prospective case-control study involving Chinese women with a singleton pregnancy who underwent preterm PE screening at 11 + 0 to 13 + 6 weeks' gestation using the FMF triple test, between February 2020 and February 2023. Women identified as being at high risk (≥ 1:100) for preterm PE by the FMF triple test were matched 1:1 with women identified as low risk (< 1:100) for maternal age ± 3 years, maternal weight ± 5 kg and date of screening ± 14 days.

The Uptake of the Influenza Vaccine in Patients With Cystic Fibrosis: A Retrospective Study.

Background: Children with cystic fibrosis are more likely to become severely unwell with influenza-associated illness compared to children without chronic lung disease. The provision of accessible influenza vaccinations is essential in the prevention of infection.

Objectives: To describe the prevalence of the influenza vaccine uptake in children with cystic fibrosis from 2016 to 2020 at a single tertiary paediatric hospital site and determine if the COVID pandemic of 2020 and the introduction of telehealth encounters affected the vaccine uptake.

Perception of Socioeconomic Status: A Meta-Analysis of Manipulations.

The causal effects of one's socioeconomic status (SES) on outcomes are typically examined by experimentally manipulating SES self-perceptions based on one of three SES dimensions-absolute resource, relative resource, and general social position. We investigated the efficacy of these manipulations by systematically meta-analyzing their effects on SES self-perceptions. Based on 107 eligible samples ( = 26,203), manipulations of SES self-perceptions across the three SES dimensions were effective overall ( = 0.