PHYSICAL THERAPY PROGRAM IN THE TREATMENT OF OSTEOARTHROSIS IN PATIENTS WITH OBESITY.

Osteoarthrosis is a family of pathological processes with multifactorial etiopathogenesis, including genetic, molecular and environmental factors, in particular, biomechanical stress. Obesity is one of the significant risk factors for osteoarthritis, increasing the risk of its development. The purpose of the research is to study the features of compiling an algorithm of physiotherapeutic interventions for patients suffering from knee osteoarthritis and obesity.

Effects of external crushing forces on a novel below-the-knee vascular implant.

Background: The Tack Endovascular System is a novel vascular implant designed to focally treat dissections with low radial force and minimal metal burden. As there are currently no approved below-the-knee (BTK) implants in the USA, a unique, 3-stage model was developed to characterize crush deformation and fracture potential of the Tack Endovascular System in BTK arteries.

Methods: First, 35 Tack implants were deployed bilaterally in the posterior tibial, anterior tibial, and peroneal arteries of 3 cadavers, and clinically relevant external forces were applied to simulate BTK crushing deformation including focal load, leg crossing, and leg bending.

An Animal Model of Human Peripheral Arterial Bending and Deformation.

Background: Designing peripheral arterial stents has proved challenging, as implanted devices will repetitively and unpredictably deform and fatigue during movement. Preclinical testing is often inadequate, given the lack of relevant animal models. The purpose of this study was to test the hypothesis that deformation of the human peripheral vasculature could be qualitatively and quantitatively modeled using an experimental animal.

Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis.

Background: Calcific atherosclerosis is a major challenge to intraluminal drug delivery in peripheral artery disease (PAD).

Objectives: We evaluated the effects of orbital atherectomy on intraluminal paclitaxel delivery to human peripheral arteries with substantial calcified plaque.

Methods: Diagnostic angiography and 3-D rotational imaging of five fresh human lower limbs revealed calcification in all main arteries.

Coronary artery rotation in native and stented porcine coronary arteries.

Introduction: Coronary arteries are exposed to several complex biomechanical forces during the cardiac cycle. These biomechanical forces potentially contribute to both native coronary artery disease, development of atherosclerosis and eventual stent failure. The aim of the present study was to characterize and define coronary artery axial rotation and the effect of stent implantation on this biomechanical factor.