Pharmaceutical industry payments to healthcare professional organisations in the United Kingdom: a seven-year cross-sectional analysis of the Disclosure UK database from 2015 to 2021.

Objectives: This study aimed to examine the size and trends in payments from the pharmaceutical industry to healthcare professional organisations (HPOs) in the United Kingdom (UK), and to characterise the conflict of interest (COI) management plans by HPOs who received large payments.

Design: Cross-sectional analysis of non-research payments disclosed in the Disclosure UK database from 2015 to 2021.

Setting: United Kingdom.

Industry marketing payments to physicians and prescription patterns for sacubitril/valsartan in the USA.

Objectives: Although financial interactions between physicians and pharmaceutical and medical device companies could be potential conflicts of interest, in certain instances, industry promotion targeted at physicians may facilitate the early adoption of effective, novel care for patients such as sacubitril/valsartan in the USA. This study aims to evaluate associations between industry-sponsored meal payments to physicians and their prescribing patterns for sacubitril/valsartan in the USA.

Methods: Using the publicly accessible Centers for Medicare and Medicaid Services Medicare Part D database and the Open Payments Database, this study assessed associations between industry-sponsored meal payments to physician prescribers and total amounts of Medicare claims and spending for sacubitril/valsartan between 2015 and 2021.

Evaluation of the Highly Ordered Structure, Ligature, and Enzymatic Degradation of Poly[()-3-hydroxybutyrate--4-hydroxybutyrate] Elastic Porous Fibers.

We prepared biocompatible elastic fibers with high porosity and high tensile strength from poly[()-3-hydroxybutyrate--4-hydroxybutyrate], which is a microbial polyester that can be produced from renewable carbon resources by isothermal crystallization. It was possible to control the pore size by adjusting the isothermal crystallization time. Most of the pores were approximately less than 10 μm in diameter, did not penetrate, and were distributed discontinuously throughout the fibers.

Financial conflicts of interest among authors of clinical practice guideline for headache disorders in Japan.

Background: Financial relationships between clinical guideline authors and pharmaceutical companies introduce conflicts of interest (COI), potentially biasing guideline recommendations. Thus, proper management of COI is paramount for clinical guideline authors. Nevertheless, little is known about COI among neurology clinical guideline authors.