Regulatory dynamics of Sch9 in response to cytosolic acidification: From spatial reconfiguration to cellular adaptation to stresses.

The regulation of cellular metabolism is crucial for cell survival, with Sch9 in serving a key role as a substrate of TORC1. Sch9 localizes to the vacuolar membrane through binding to PI(3,5)P, which is necessary for TORC1-dependent phosphorylation. This study demonstrates that cytosolic pH regulates Sch9 localization.

[Contrivance to Use Ultrasonic Scalpel for Laparoscopic Surgery during Internal Thoracic Artery Harvest].

From April 2024, manufacturing of short-shaft ultrasonic scalpels( SNGHK) has ceased. A scalpel for laparoscopic surgery (HDH05) remains available;however, its long shaft is unsuitable for internal thoracic artery harvesting through a median sternotomy. We contrived to make the latter device easier to handle using a method that requires no specialized parts.

[Utility of abdominal ultrasonography in the management of ulcerative colitis:proposal of a new scoring system].

In the management of ulcerative colitis (UC), colonoscopy (CS) is considered essential for diagnosis;however, its invasiveness poses a challenge. Conversely, recent advancements in ultrasound diagnostic devices have improved imaging quality for the digestive tract, rendering them valuable in UC management. Therefore, this study aimed to elucidate the correlation between abdominal ultrasonography (AUS) and CS in assessing UC activity.

Designing a test battery for workers' well-being: the first wave of the Tsukuba Salutogenic Occupational Cohort Study.

Background: In recent years, there has been a diversification of working styles. The concept of workers' well-being is no longer limited to material wealth, such as how satisfied they are with their wages. Psychological enrichment, encompassing factors like motivation and interpersonal relationships, is also important.