Publications by authors named "A Y Manzur"
Obstructive Sleep Apnoea (OSA) is associated with the development of cardiovascular disease (CVD); however, the risk is only weekly related to OSA severity traditionally determined by the apnoea-hypopnoea index. The Baveno classification was developed to improve patient selection who would benefit from OSA treatment in terms of symptoms improvement and CVD risk reduction. However, it is unclear how the classification relates to biomarkers of CVD risk.
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- The NorthStar Ambulatory Assessment (NSAA) total score (TS) is used to track disease progression and treatment effects in children with Duchenne Muscular Dystrophy (DMD).
- This study analyzes TS performance patterns in young individuals, focusing on their walking/running and rising abilities, and compares trends in those whose condition is stable versus declining.
- The findings aim to enhance clinical management by linking TS trends to therapy standards, helping families and therapists make informed treatment decisions.
Article Synopsis
- Short bowel syndrome is a rare condition with limited existing data, prompting a registry study in Latin America focused on chronic intestinal failure, analyzing various patient and clinical factors from specialized centers.
- From May 2020 to July 2023, the study included 167 patients (115 adults and 52 children) across 20 centers, revealing key demographics, complications, and outcomes, with significant differences between adults and children in terms of etiology and follow-up results.
- The findings aim to enhance understanding of intestinal failure in Latin America, serving as both a data repository and an educational resource for healthcare teams, while striving for international recognition of regional health challenges.
Background And Purpose: Treatment with glucocorticoids (GCs) is part of the standard of care in Duchenne muscular dystrophy, but excess weight gain and height stunting are common side-effects. It is still unclear how these growth-related side-effects affect motor function.
Methods: This retrospective cohort study utilized 2228 observations from 648 participants in the UK NorthStar database who had growth and ambulation data recorded between 2006 and 2020.
Article Synopsis
- - This study investigates the effects of scoliosis surgery on various outcomes (respiratory function, motor function, weight, pain, and patient satisfaction) in patients with spinal muscular atrophy (SMA), highlighting the lack of research on these secondary outcomes.
- - Results showed significant improvement in respiratory function for SMA2 patients postsurgery, but some experienced drops in gross motor scores and weight, with many reporting postsurgical pain, especially hip-related.
- - Despite these challenges, patients and parents expressed overall satisfaction with the surgery's impact on posture and appearance, emphasizing the need for better postoperative care, including physiotherapy and support services.