Lumbar total disk replacement versus microsurgical lumbar discectomy in treatment of radicular and back pain in railway workers: a prospective randomized controlled trial.

Background: Currently, there remains a high percentage of complications after lumbar discectomy, while there is no uniform tactic to prevent their development. Purpose of the study was to compare the clinical efficacy and return to work rate (RWR) after total disk replacement (TDR) and microsurgical lumbar discectomy (MLD) in railway workers with lumbar disk herniation (LDH).

Methods: We randomly assigned 75 patients out of a total of 81 patients, between 25 and 35 years of age who had one level LDH to undergo single-level TDR surgery (group I, n=37) or MLD surgery (group II, n=38) in the L4-L5 or L5-S1 segments.

Artificial Tertiary Lymphoid Structures: Exploring Mesenchymal Stromal Cells as a Platform for Immune Niche Formation.

Constructing artificial tertiary lymphoid structures (TLSs) opens new avenues for advancing cancer immunotherapy and personalized medicine by creating controllable immune niches. Mesenchymal stromal cells (MSCs) offer an ideal stromal source for such constructs, given their potent immunomodulatory abilities and accessibility. In this study, we explored the potential of adipose-derived MSCs to adopt TLS-supportive phenotypes and facilitate lymphocyte organization.

[Postoperative outcomes after simultaneous surgery for cervical radiculopathy combined with distal peripheral nerve compression].

Unlabelled: To date, the optimal therapeutic and diagnostic strategy in patients with simultaneous clinical manifestations of degenerative cervical spine disease and upper-extremity nerve compression is still unclear.

Objective: To analyze the results of simultaneous surgical interventions in patients with cervical radiculopathy combined with distal peripheral compression-induced ischemic neuropathy.

Material And Methods: We retrospectively studied postoperative outcomes in 23 patients with two-level degenerative cervical spine disease with radiculopathy and peripheral nerve compression (cubital canal, Guyon's canal or carpal tunnel syndromes).

A New Neuroanesthetic Protocol of Rendering Specialized Care in Treating Degenerative Lumbar Spine Diseases in High-Risk Patients: Prospective Analysis of the Results.

Unlabelled: is to assess the effectiveness of a new neuroanesthetic protocol for treating degenerative lumbar spine diseases in high-risk patients.

Materials And Methods: Two groups of patients with a high risk of anesthesia and surgery determined by the authors' clinical decision support system (CDSS) have been prospectively studied. A new neuroanesthetic protocol was used in the experimental group (EG, n=25), while the control group (CG, n=25) underwent intravenous anesthesia based on propofol and fentanyl.

[The comparative analysis of dorsopathy morbidity of adult population in the Russian Federation and separate Subjects of the Northern-West Federal Okrug in 2013-2022].

The dorsopathy is among of common causes of restriction of human life activity, affecting one's working capacity and quality of life. The purpouse of the study was to carry out comparative analysis of dorsopathy and spondylopathy morbidity of adult population in the Russian Federation and the Subjects of the Northern-West Federal Okrug in dynamics in 2013-2022. The statistical data of the Federal State Budget Institution "The Central Research Institute for Health Organization and Informatics of Minzdrav of Russia" was used.