Microdissection of Distinct Morphological Regions Within Uveal Melanomas Identifies Novel Drug Targets.

: Uveal melanomas (UMs) are rare but often deadly malignancies that urgently require viable treatment options. UMs often exhibit tumour heterogeneity, with macroscopic and microscopic differences in morphology between different regions of the same tumour. However, to date, the clinical significance of this and how it may help guide personalised therapy have not been realised.

Common pitfalls and diagnostic challenges in the application of LI-RADS CT/MRI algorithms: a comprehensive review.

The Liver Imaging Reporting and Data System (LI-RADS) was developed to standardize the interpretation and reporting of liver observations in at-risk populations, aiding in the diagnosis of hepatocellular carcinoma (HCC). Despite its advantages, the application of LI-RADS can be challenging due to the complexity of liver pathology and imaging interpretation. This comprehensive review highlights common pitfalls encountered in LI-RADS application and offers practical strategies to enhance diagnostic accuracy and consistency among radiologists.

Retropupillary Iris Clip Intraocular Lenses: A Case Series of 57 Eyes.

Purpose: To report visual and refractive outcomes and intraoperative and postoperative complications after pars plana vitrectomy (PPV) with retropupillary implantation of an iris clip intraocular lens (IOL).

Methods: This is a retrospective case series of patients who underwent secondary retropupillary intraocular lens insertion combined with pars plana vitrectomy to treat aphakia secondary to a dislocated nucleus lens (group A); or IOL dislocation (group B). Patient demographics, preoperative visual and refractive outcomes, intraoperative factors, postoperative visual and refractive outcomes, and complications within the follow-up period ranging from 6 months up to 3 years postoperative, were recorded.

Barriers to integration of health and equity into urban design policies in Regina, Saskatchewan.

Although there is extensive literature on the impact of urban design on health, little is known about the barriers to integrating health into urban design policies. As cities increasingly lead efforts to improve health equity and population health, understanding the perspectives and experiences of municipal actors on health and equity is essential. To address this gap, we conducted semi-structured interviews with 30 stakeholders engaged with urban design policy- and decision-making at the City of Regina in Saskatchewan, Canada.