Publications by authors named "A Y Dagnra"
HIV self-testing: A highly acceptable and feasible strategy for reconnecting street adolescents with HIV screening and prevention services in Togo (The STADOS study).
PLoS One
October 2024
Introduction: HIV self-testing is a complementary screening strategy that could facilitate access to HIV care services for street adolescents. The objectives of this study were to assess the acceptability and feasibility of HIV self-testing and their associated factors, to estimate HIV prevalence among street adolescents in Togo, and to describe the sexual behavior of this population.
Methods: A cross-sectional study was conducted between July 2021 and May 2022 in Lomé and Kara (Togolese cities with the highest number of street adolescents).
Article Synopsis
- * A study involving 30 Togolese female sex workers analyzed 156 HPV genome sequences from cervical and anal swabs, revealing identical infections but varying genetic diversity across HPV types and sites.
- * Low-risk HPVs showed more mutations induced by APOBEC3 in the E4 and E6 genes compared to high-risk HPVs, which had fewer mutations, suggesting different cancer risk potentials among HPV types.
Background: In Togo, few data are available on viral hepatitis in street adolescents, a vulnerable population due to their lifestyle. The aim of this study was to describe the lifestyle of street adolescents (sexual practices and drug use), to estimate the prevalence of hepatitis B and C viruses, and to describe their HBV immunization profile in Togo.
Methods: A cross-sectional study was conducted in Lomé (Togo) in July 2021.
Objectives: Widespread testing and treatment are essential to eliminate hepatitis B virus (HBV) infection as a public health concern. However, in resource-limited countries, access to HBV PCR is limited. In this study, we developed a quantitative HBV PCR assay on open molecular platforms and evaluate its performance in diagnosing clinically significant HBV DNA thresholds as defined by the WHO (2000 IU/mL, 20 000 IU/mL, and 200 000 IU/mL).
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- Integrase strand transfer inhibitors (INSTIs) are now the recommended first-line treatment for HIV in low- and middle-income countries due to rising resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs).
- A study analyzed samples from West Africa and Southeast Asia to assess the prevalence of pretreatment drug resistance (PDR) to INSTIs, finding a low frequency of 1.1% while overall PDR to any drug class was significantly higher at 17.9%.
- The findings advocate for the use of INSTIs in these regions yet highlight the urgent need to prevent further drug resistance to ensure effective treatment outcomes.