Publications by authors named "A Xhaard"
Objective: Febrile neutropenia (FN) is a serious clinical event, associated with significant morbidity and mortality. Imaging has a central role in the identification of the fever cause. The study objectives were to assess abnormalities of potential infectious origin on paranasal sinus, chest and abdomen/pelvis CT scans performed during an episode of FN, in patients with or without specific clinical signs, and to evaluate their impact on the frequency of changes in treatment.
View Article and Find Full Text PDFAntihuman T Lymphocyte Globulin Fresenius in Graft-Versus-Host Disease Prophylaxis for Unrelated Hematopoietic Stem Cell Transplantation After Myeloablative Conditioning: A Long-Term Real-Life Retrospective Study.
Marion Divoux Matthieu Resche-Rigon David Michonneau Aurélien Sutra Del Galy Nathalie Dhedin Alienor Xhaard
Am J Hematol
December 2024
Article Synopsis
- Recent guidelines suggest using quantitative PCR (qPCR) to guide early treatment for toxoplasmosis in patients who received allogeneic hematopoietic cell transplantation (allo-HCT).
- A study analyzing qPCR data from 85 patients found that higher initial parasitic loads were linked to slower clearance and increased mortality risk if patients didn't reach negativity within ten days.
- The findings indicate that monitoring qPCR kinetics can help clinicians identify high-risk patients, prompting potential adjustments to their treatment if necessary.
Article Synopsis
- Donor cell engraftment is necessary for successful stem cell transplantation, but the cellular interactions in bone marrow during this process have not been well understood.
- Researchers used mass cytometry and CITEseq to analyze bone marrow cells three months after transplantation in patients with leukemia, finding significant changes in myeloid and B-cell progenitors, indicating a shift towards inflammation-driven hematopoiesis.
- The study concluded that bone marrow engraftment is marked by emergency hematopoiesis and an inflammatory response, particularly in patients who experienced graft-versus-host disease (GVHD).
Article Synopsis
- - The study analyzed mucormycosis cases over 15 years at a French center, reviewing medical records and introducing qPCR for better diagnosis in 2015.
- - A total of 77 patients were examined, primarily with hematological diseases, and common infection sites included the lungs and sinuses. Diagnosis was challenging, with qPCR aiding in 30% of cases.
- - The overall survival rate was low at 40%, but combining surgical and antifungal treatments significantly improved patient outcomes, particularly for those with hematological issues and burns.