Publications by authors named "A Wunderlich"
Nutritional status during the developmental periods leads to predisposition to several diseases and comorbidities, highlighting metabolic and reproductive changes throughout adult life, and in the next generations. One of the experimental models used to induce undernutrition is litter size expansion, which decreases the availability of breast milk to pups and delays development. This work evaluated the effects of maternal undernutrition induced by litter size expansion, a maternal undernutrition preconception model, on the metabolic and reproductive alterations of the offspring.
View Article and Find Full Text PDFEstrogens impair hypophagia and hypothalamic cell activation induced by vasoactive intestinal peptide, but not by pituitary adenylate cyclase-activating polypeptide.
Peptides
January 2025
Article Synopsis
- The study investigated how estradiol affects food intake and receptor expression in postmenopausal rats, particularly looking at the neuropeptides VIP and PACAP in specific hypothalamic areas.
- Results showed that estradiol reduced the expression of the VPAC2 receptor and disrupted the hypophagic (appetite-reducing) effects of VIP, while PACAP continued to suppress food intake.
- Additionally, estradiol altered plasma glucose and free fatty acid levels in these rats, suggesting different mechanisms in how VIP and PACAP influence energy homeostasis in the context of estrogen loss.
Background: Sitting is known to be bad for your cardiovascular health. We furthermore hypothesized that sitting posture will reduce perfusion of the foot and increase edema, possibly predisposing to disease like osteochondritis.
Methods: We included 27 healthy volunteers and performed MRI measurements including arterial spin labelling (ASL) and intravoxel incoherent motion (IVIM) perfusion as well as short tau inversion recovery (STIR) edema measurement and 3D volumetry.
Article Synopsis
- Several maternal undernutrition models show that male offspring experience testicular development issues and compromised sperm production.
- In this study, male pups were raised in either normal or larger litters, and at 90 days old, were assessed for sexual behavior and various tissue analyses.
- Although the undernourished males had histological changes in their testes, including abnormal tubules and fewer Sertoli cells, their sperm quality and sexual behaviors remained unaffected.
Background: Hearing impairments are a rising burden in our aging society. Hearing loss is associated with reduced cognitive performance as well as decrements in balance and gait. Therefore, impaired hearing affects also dual tasking (DT).
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