Publications by authors named "A Wolthuis"
Article Synopsis
- A case series highlights positive results for patients with gastrointestinal (GI) cancer characterized by deficient mismatch repair (dMMR) who underwent surgery to remove a single worsening tumor while undergoing immunotherapy.
- The study shows that this combined approach of surgery and immunotherapy can lead to excellent patient outcomes.
- These findings suggest that carefully selected patients with dMMR GI cancer may benefit significantly from this treatment strategy.
Thyroid-stimulating hormone (TSH) and subsequent free thyroxine (FT4) concentrations outside the reference interval (RI) are used to diagnose thyroid diseases. Most laboratories do not provide age-specific RIs for TSH and FT4 beyond childhood, although TSH concentrations vary with age. Therefore, we aimed to establish TSH and FT4 age-specific RIs throughout life and aimed to determine whether using these RIs would result in reclassification of thyroid disease diagnoses in adults.
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- The study aimed to compare various total mesorectal excision (TME) techniques combined with sphincter-sparing procedures in high-risk rectal cancer patients.
- It involved a multicenter trial with over 1,000 patients, analyzing techniques like laparotomy, laparoscopy, robotic-assisted surgery, and transanal surgery to assess surgical outcomes.
- Results indicated that while all techniques had similar rates of successful resections, none met the anticipated success rate, and the outcomes were comparable among different surgical approaches, especially for minimally invasive methods.
Crohn's disease (CD) is marked by recurring intestinal inflammation and tissue injury, often resulting in fibrostenosis and bowel obstruction, necessitating surgical intervention with high recurrence rates. To elucidate the mechanisms underlying fibrostenosis in CD, we analyzed the transcriptome of cells isolated from the transmural ileum of patients with CD, including a trio of lesions from each patient: non-affected, inflamed, and stenotic ileum samples, and compared them with samples from patients without CD. Our computational analysis revealed that profibrotic signals from a subset of monocyte-derived cells expressing CD150 induced a disease-specific fibroblast population, resulting in chronic inflammation and tissue fibrosis.
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