Publications by authors named "A Wisser"
Article Synopsis
- The study aimed to see if changes in MRI-defined bone marrow lesions (BMLs) and inflammatory markers are linked to cartilage loss in knees with osteoarthritis over 24 months.
- It analyzed data from 629 participants, finding that knees with no BMLs showed significantly less cartilage loss, while those with increasing BML size experienced more cartilage loss.
- The results suggest that preventing the growth of BMLs and worsening of Hoffa-synovitis could help reduce cartilage deterioration in osteoarthritis patients.
Objective: A fully automated laminar cartilage composition (MRI-based T2) analysis method was technically and clinically validated by comparing radiographically normal knees with (CL-JSN) and without contra-lateral joint space narrowing or other signs of radiographic osteoarthritis (OA, CL-noROA).
Materials And Methods: 2D U-Nets were trained from manually segmented femorotibial cartilages (n = 72) from all 7 echoes (All), or from the 1st echo only (1) of multi-echo-spin-echo (MESE) MRIs acquired by the Osteoarthritis Initiative (OAI). Because of its greater accuracy, only the All U-Net was then applied to knees from the OAI healthy reference cohort (n = 10), CL-JSN (n = 39), and (1:1) matched CL-noROA knees (n = 39) that all had manual expert segmentation, and to 982 non-matched CL-noROA knees without expert segmentation.
The design of a sample rapid magnetic resonance imaging (MRI) acquisition protocol supporting assessment of multiple articular tissues and pathologies in knee osteoarthritis.
Osteoarthr Cartil Open
September 2024
Article Synopsis
- - The article outlines a proposed MRI acquisition protocol for clinical trials involving knee osteoarthritis, focusing on both early and advanced stages of the disease while supporting automated data analysis for specific imaging endpoints.
- - A comprehensive literature review and expert input were utilized to determine optimal MRI techniques, ensuring that the protocols can be executed within 30 minutes on standard clinical equipment.
- - The authors emphasize the importance of acquiring high-quality, longitudinal MRIs that include specific sequences for analyzing cartilage and synovitis, aiming to enhance scientific research in disease progression and treatment efficacy.
Background: Magnetic resonance imaging (MRI) cartilage transverse relaxation time (T2) reflects cartilage composition, mechanical properties, and early osteoarthritis (OA). T2 analysis requires cartilage segmentation. In this study, we clinically validate fully automated T2 analysis at 1.
View Article and Find Full Text PDFObjective: We here explore whether observed treatment effects of a putative disease-modifying osteoarthritis drug (DMOAD) are greater when cartilage morphometry is performed with rather than without knowledge of magnetic resonance imaging (MRI) acquisition order (unblinded/blinded to time point).
Methods: In the FORWARD (FGF-18 Osteoarthritis Randomized Controlled Trial with Administration of Repeated Doses) randomized controlled trial, 549 knee osteoarthritis patients were randomized 1:1:1:1:1 to three once-weekly intra-articular injections of placebo, 30 µg sprifermin every 6 or 12 months (M), or 100 µg every 6/12 M. After year 2, cartilage segmentation of BL through 24 M MRIs was performed, with blinding to acquisition order.