Publications by authors named "A Winters"
Objectives: This study aims to explore the impact of telehealth on buprenorphine prescribing and retention in care for patients with opioid use disorder (OUD) seen at a large federally qualified health center (FQHC) the year prior to and following the start of the COVID-19 pandemic.
Methods: We conducted a retrospective study of patients with OUD and at least one medical visit to the FQHC between March 1, 2019, and February 28, 2021. This study utilized March 1, 2020, to delineate the beginning of COVID as the FQHC widely instituted telehealth during the month in response to the pandemic.
Aims: In light of the evidence supporting a significant role of the gut microbiome in Gulf War Illness (GWI) pathology, we sought to examine its contribution to GWI susceptibility in a mouse model. We also aimed to identify bacterial taxa and microbially-derived metabolites associated with disease susceptibility.
Main Methods: Male mice receiving pyridostigmine bromide (PB) orally, and controls were evaluated for symptoms of GWI at 8 weeks post-treatment.
Article Synopsis
- The study investigates the role of BAG3 genetic variants in heritable dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), focusing on how these variants contribute to the variability in disease expression and severity.
- Conducted at the University of Pennsylvania Health System, the research included a large cohort of patients, using whole-exome sequencing linked to electronic health records to analyze associations between BAG3 variants and clinical traits.
- Results indicated that the common C151R BAG3 variant is linked to a lower risk of DCM but an increased risk of HCM, with carriers showing better long-term health outcomes compared to noncarriers.
Preterm birth (PTB), often preceded by preterm labor, is a major cause of neonatal morbidity and mortality worldwide. Most PTB cases involve intra-amniotic inflammation without detectable microorganisms, termed in utero sterile inflammation, for which there is no established treatment. In this study, we propose homeostatic macrophages to prevent PTB and adverse neonatal outcomes caused by in utero sterile inflammation.
View Article and Find Full Text PDFLiver transplantation (LT) is the only curative treatment for end-stage liver disease and significantly improves patient outcomes. However, LT is resource-intensive and costly, with expenditures rising dramatically in recent years. Factors contributing to this increase in cost include expanded transplant criteria, utilization of marginal organs, and broader organ distribution, resulting in significant logistical expenses.
View Article and Find Full Text PDF