Publications by authors named "A Win"

Article Synopsis
  • Colorectal cancers (CRCs) linked to biallelic germline variants show specific mutational signatures (SBS18+SBS36 and SBS30) that could also be present in adenomas, which are precursors to CRCs.
  • A study sequenced DNA from adenomas and CRCs in biallelic cases and compared them with sporadic cases to investigate these signatures.
  • Results indicated that adenomas in biallelic cases had similar mutational signature proportions as their corresponding CRCs, suggesting testing adenomas could enhance the detection of biallelic cases and improve variant classification for better CRC prevention strategies.
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Exciton dynamics of perovskite nanoclusters has been investigated for the first time using femtosecond transient absorption (TA) and time-resolved photoluminescence (TRPL) spectroscopy. The TA results show two photoinduced absorption signals at 420 and 461 nm and a photoinduced bleach (PB) signal at 448 nm. The analysis of the PB recovery kinetic decay and kinetic model uncovered multiple processes contributing to electron-hole recombination.

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Article Synopsis
  • Survivors of colorectal cancer are at risk for developing a second primary colorectal cancer, termed metachronous colorectal cancer, and identifying features of the first tumor could help improve surveillance strategies.
  • In a study of 6085 colorectal cancer cases from the Colon Cancer Family Registry, 138 (2.3%) developed metachronous CRC over an average follow-up of 12 years, with specific factors influencing their risk.
  • Notably, individuals with synchronous tumors were 3.4 times more likely, and those with MMR-deficient tumors had a 72% higher risk, while those with an undifferentiated histologic type were 77% less likely to develop a second cancer. Existing surveillance guidelines may need
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Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 154,587 controls of East Asian and European ancestry. Our stepwise conditional analyses revealed 238 independent association signals of CRC risk, each with a set of credible causal variants (CCVs), of which 28 signals had a single CCV.

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Young breast and bowel cancers (e.g., those diagnosed before age 40 or 50 years) have far greater morbidity and mortality in terms of years of life lost, and are increasing in incidence, but have been less studied.

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