Associations of Coffee and Tea Consumption on Neural Network Connectivity: Unveiling the Role of Genetic Factors in Alzheimer's Disease Risk.

Background: Coffee and tea are widely consumed beverages, but their long-term effects on cognitive function and aging remain largely unexplored. Lifestyle interventions, particularly dietary habits, offer promising strategies for enhancing cognitive performance and preventing cognitive decline.

Methods: This study utilized data from the UK Biobank cohort ( = 12,025) to examine the associations between filtered coffee, green tea, and standard tea consumption and neural network functional connectivity across seven resting-state networks.

A multi-stage feature selection method to improve classification of potential super-agers and cognitive decliners using structural brain MRI data-a UK biobank study.

Cognitive aging is described as the age-related decline in areas such as memory, executive function, reasoning, and processing speed. Super-Agers, adults over 80 years old, have cognitive function performance comparable to middle-aged adults. To improve cognitive reserve and potentially decrease Alzheimer's disease (AD) risk, it is essential to contrast changes in regional brain volumes between "Positive-Agers" who have superior cognitive performance compared to their age peers but are not 80 years old yet and aging adults who show cognitive decline (i.

Manganese Exposure Enhances the Release of Misfolded α-Synuclein via Exosomes by Impairing Endosomal Trafficking and Protein Degradation Mechanisms.

Excessive exposure to manganese (Mn) increases the risk of chronic neurological diseases, including Parkinson's disease (PD) and other related Parkinsonisms. Aggregated α-synuclein (αSyn), a hallmark of PD, can spread to neighboring cells by exosomal release from neurons. We previously discovered that Mn enhances its spread, triggering neuroinflammatory and neurodegenerative processes.

Endometrial Proliferation and Heavy Menstrual Bleeding Associated With Continuous Oral Contraceptive Use.

Continuous oral contraceptives are intended for three months of levonorgestrel/ethinylestradiol use followed by 10 days of low-dose ethinylestradiol. When taken for extended periods without withdrawal bleeds, side effects may include heavy menstrual bleeding and endometrial proliferation. A 41-year-old female presented to the OB-GYN clinic with two months of heavy menstrual bleeding after 10 years of Seasonique use without withdrawal bleeds (10 days of low-dose ethinylestradiol).