Publications by authors named "A Wiegering"
Importance: There is conflicting evidence regarding weekday dependent outcome in complex abdominal surgery, including pancreatic resections.
Objective: To clarify weekday-dependency of outcome after pancreatic resections in a comprehensive nationwide context.
Design: Retrospective cross-sectional study of anonymized nationwide hospital billing data (DRG data).
The contribution of deubiquitylating enzymes (DUBs) to β-Catenin stabilization in intestinal stem cells and colorectal cancer (CRC) is poorly understood. Here, and by using an unbiassed screen, we discovered that the DUB USP10 stabilizes β-Catenin specifically in APC-truncated CRC in vitro and in vivo. Mechanistic studies, including in vitro binding together with computational modelling, revealed that USP10 binding to β-Catenin is mediated via the unstructured N-terminus of USP10 and is outcompeted by intact APC, favouring β-catenin degradation.
View Article and Find Full Text PDFMolecular Profiling of Low-Grade Appendiceal Mucinous Neoplasms (LAMN).
Genes Chromosomes Cancer
October 2024
Low-grade appendiceal mucinous neoplasia (LAMN) represents a relatively rare tumor of the appendix typically diagnosed incidentally through appendectomy for acute appendicitis. In cases where perforation occurs, mucinous content may disseminate into the abdominal cavity, leading to the development of pseudomyxoma peritonei (PMP). The primary objective of this study was to elucidate the molecular characteristics associated with various stages of LAMN and PMP.
View Article and Find Full Text PDFArticle Synopsis
- A study compared minimally-invasive gastrectomy and open surgery, finding that the former provides similar cancer outcomes with fewer complications and shorter recovery times for gastric cancer patients in Europe.
- Data was collected from primary bariatric surgeries and subsequent minimally-invasive gastrectomies, focusing on operation time, lymph node yield, and postoperative complications.
- Results indicated that surgeons improved their skills over time, achieving high cancer removal rates, and overall safe outcomes, although robotic surgery had longer operation times compared to laparoscopic techniques.
Unraveling the role of local ablative therapies for patients with metastatic soft tissue sarcoma - A retrospective multicenter study of the Bavarian university hospitals.
Eur J Surg Oncol
December 2024
Background: Local ablative therapies (LAT) are increasingly used in patients with metastatic soft tissue sarcoma (STS), yet evidence-based standards are lacking. This study aimed to assess the impact of LAT on survival of metastatic STS patients and to identify prognostic factors.
Methods: In this retrospective multicenter study, 246 STS patients with metastatic disease who underwent LAT on tumor board recommendation between 2017 and 2021 were analyzed.