BMIgap: a new tool to quantify transdiagnostic brain signatures of current and future weight.

Understanding the neurobiological underpinnings of weight gain could reduce excess mortality and improve long-term trajectories of psychiatric disorders. We used support-vector machines and whole-brain voxel-wise grey matter volume to generate and validate a BMI predictor in healthy individuals (N = 1504) and applied it to individuals with schizophrenia (SCZ,N = 146), clinical high-risk states for psychosis (CHR,N = 213) and recent-onset depression (ROD,N = 200). We computed BMIgap (BMI-BMI), interrogated its brain-level overlaps with SCZ and explored whether BMIgap predicted weight gain at 1- and 2-year follow-up.

Periodontal health in teeth treated with deep-margin-elevation and CAD/CAM partial lithium disilicate restorations-a prospective controlled trial.

Objectives: This prospective controlled clinical trial aimed to compare periodontal parameters of proximal deep-margin-elevation (DME) restoration margins with supragingival/equigingival restoration margins (control) on the opposite proximal surface of the same tooth.

Materials And Methods: Subgingival one-sided proximal defects (mesial or distal) on (pre-)molars were restored with composite DME and CAD/CAM-manufactured lithium disilicate ceramic partial-coverage restorations. Periodontal parameters (bleeding on probing (BOP), periodontal probing depths (PPD), plaque index (PI)) were recorded after insertion of the ceramic restoration (baseline) and at 1-year recall visit and compared between DME and control on the same tooth (Fisher's exact test and Wilcoxon signed rank test, p < 0.

Depressive and Anxiety Symptoms Were More Common for Transgender Individuals Whose Gender-Affirming Surgeries Were Cancelled or Delayed Due to COVID-19: A Global Cross-Sectional Study.

Gender-affirming surgeries, which have well-established mental health benefits, were cancelled and delayed for transgender people worldwide during the COVID-19 crisis. Of 253 scheduled gender-affirming surgeries among transgender adults across 35 countries in late 2020, 27% (=69) reported that the COVID-19 crisis limited their access to gender-affirming surgery (i.e.

Repair of partially defective restorations: Systematic review and meta-analysis of patient acceptance.

Objectives: This systematic review attempted to assess patient acceptance of repairs instead of complete replacement for partially defective restorations and to identify factors affecting patients' decision-making for or against repairs.

Study Selection: Observational and qualitative studies reporting on (1) the proportion of patients accepting or preferring repairs, (2) the proportion of dentists / dental students / dental schools stating that their patients accept or prefer repairs, (3) factors affecting patients' decision-making for or against repairs.

Sources: Electronic databases (MEDLINE via PubMed, Scopus, EMBASE via Ovid, and Web of Science) were last searched in August 2024 (PROSPERO database: CRD42023449437).

DNA Methylation of Is Associated with Early-Life Adversity in Adult Mental Disorders.

Early-life adversity (ELA) is characterized by exposure to traumatic events during early periods of life, particularly involving emotional, sexual and/or physical adversities during childhood. Mental disorders are strongly influenced by environmental and lifestyle-related risk factors including ELA. However, the molecular link between ELA and the risk of an adult mental disorder is still not fully understood.