Phosphate supplementation in young men: lack of effect on calcium homeostasis and bone turnover.

Objective: To examine the effect of phosphate supplements on calcium homeostasis and bone turnover in young men.

Design: Study 1 was a randomised, controlled, cross-over trial of 1000 mg elemental phosphate given for one week, with a standard diet of 800 mg/d each of calcium and phosphorus. Study 2 was an escalating dose study of 0, 1000, 1500 and 2000 mg/d elemental phosphate, each given for one week, with a standard diet of 1000 mg/d each of calcium and phosphate.