Publications by authors named "A Wenners"
Background: High mobility group A proteins are involved in chromatin remodeling, thereby influencing multiple fundamental biological processes. HMGA2 has been linked to oncogenic traits among a variety of malignancies.
Objective: To determine the prognostic implications of subcellular distribution patterns of HMGA2 in breast cancer.
Upon ligand binding, plasma membrane-located TNF-related apoptosis-inducing ligand (TRAIL)-receptors 1 and 2 induce apoptosis as well as cancer-promoting signaling in cancer cells. TRAIL-R3 and TRAIL-R4 are believed to negatively regulate TRAIL-mediated apoptosis. Intracellular localization of TRAIL-receptors, as observed in many tumor cells, has been associated with oncogenic features, which are distinct from membrane-associated TRAIL-R signaling.
View Article and Find Full Text PDFTumor-infiltrating lymphocytes (TILs) in breast cancer are a key representative of the tumor immune microenvironment and have been shown to provide prognostic and predictive biomarkers. The extent of lymphocytic infiltration in tumor tissues can be assessed by evaluating hematoxylin and eosin (H&E)-stained tumor sections. We investigated tissue microarrays of 31 invasive breast cancer patients, looking at quantity and topological distribution of CD3+, CD8+, CD20+, Ki67+, FoxP3+ TILs and CD3+/FoxP3+, CD8+/FoxP3+ cell ratios.
View Article and Find Full Text PDFBackground: The numerous side effects of chemotherapy in patients with breast cancer are well known. However, the precise effects of chemotherapy on ovarian function in premenopausal women are poorly investigated. The patients are at risk of developing sexual hormone deficiency and impaired fertility.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on tumor surgery in breast cancer, highlighting the challenge of removing all tumor cells, particularly at the invasion front, where cells undergo a change that aids in invasion.
- The research analyzed tissue from 352 breast cancer patients, looking for the EMT factor Snail and different immune cells (FoxP3, CD3, and CD8) in the tumor environment.
- Findings indicate that higher levels of Snail correlate with better survival rates, and the presence of FoxP3 is particularly linked to improved outcomes, suggesting these could be important prognostic markers in breast cancer.