Objective: To report outcomes from routine clinical practice of liver transplantation (LT) following normothermic liver machine perfusion (NLMP) and compare to LT after static cold storage (SCS).
Background: NLMP is emerging as a clinical routine in LT as has recently received renewed attention, however outcomes outside of clinical trials are lacking.
Methods: All adult LT between February 2018 and January 2023 were included.
In captivity, neotropical Seba's short-tailed bats () (Chiroptera: Phyllostomidae) reproduce readily, and contraception can constitute an opportunity to prevent uncontrolled reproduction, which can lead to overpopulation as well as inbreeding. The authors developed a safe and efficient work flow, anesthetic, and surgical castration protocol for the reproductive control of a captive population of more than 500 bats housed at the rainforest house at the Vienna Zoo, Austria. An anesthetic protocol using 0.
View Article and Find Full Text PDFThe programmed cell death protein 1 (PD-1) acts as a central inhibitory immune checkpoint receptor. The soluble form of its primary ligand, sPD-L1, was found to be elevated in serum of patients with cancer, infectious diseases and chronic inflammation. So far, the hepatic origin of sPD-L1 has received relatively little attention and is therefore subject of this study in the context of normothermic machine perfusion (NMP) of liver grafts.
View Article and Find Full Text PDFBackground: A better understanding of the molecular events during liver normothermic machine perfusion (NMP) is warranted to develop a data-based approach for the identification of biomarkers representative of graft quality and posttransplant outcome. We analysed the dynamic transcriptional changes during NMP and linked them to clinical and biochemical parameters.
Methods: 50 livers subjected to NMP for up to 24 h were enrolled.